|Title:||Sulfamoyl substituted phenethylamine intermediates|
|Abstract:||Pharmaceutical compositions are provided for the treatment of disorders in a subject, such as hypertension, congestive heart failure, angina pectoris, lower urinary tract dysfunction and prostatic hypertrophy. The compositions when administered to a subject produce an .alpha.-adrenergic blocking action and contain as an active ingredient sulfamoyl-substituted phenethylamine derivatives, such as optically active 5-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl-2-methoxybenzenesulfonam ide, and a pharmaceutically acceptable carrier.|
|Inventor(s):||Niigata; Kunihiro (Saitama, JP), Fujikura; Takashi (Saitama, JP)|
|Assignee:||Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JP)|
|Filing Date:||Dec 28, 1993|
|Claims:||1. A compound of the formula ##STR87## wherein R.sub.1 represents an amino group or a mono- or di-lower alkylamino group; R.sub.2 represents a hydroxyl group, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents hydrogen, halogen, a lower alkyl group, a lower alkoxy group, a phenylthio group, or a phenysulfinyl group; R.sub.4 represents hydrogen or a lower alkyl group, and acid addition salts thereof. |
2. The compound of claim 1 wherein R.sub.1 represents a mono- or di-lower alkylamino group; R.sub.2 represents a lower alkoxy group; R.sub.3 represents hydrogen and R.sub.4 a lower alkyl group.
3. The compound of claim 1 wherein R.sub.1 represents methylamino; R.sub.2 represents methoxy; R.sub.3 represents hydrogen and R.sub.4 represents methoxy.
4. The compound of claim 1 wherein R.sub.1 represents dimethylamino; R.sub.2 represents methoxy; R.sub.3 represents hydrogen and R.sub.4 represents methoxy.