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Details for Patent: 5,368,859

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Details for Patent: 5,368,859

Title: Biodegradable system for regenerating the periodontium
Abstract:Methods are described for assisting the restoration of periodontal tissue in a periodontal pocket and for retarding migration of epithelial cells along the root surface of a tooth. The methods involve placement of an in-situ forming biodegradable barrier adjacent the surface of a tooth. The barrier is microporous and includes pores of defined size. The barrier can include a biologically active agent.
Inventor(s): Dunn; Richard L. (Fort Collins, CO), Tipton; Arthur J. (Fort Collins, CO), Southard; George L. (Fort Collins, CO), Rogers; Jack A. (Fort Collins, CO)
Assignee: Atrix Laboratories, Inc. (Fort Collins, CO)
Filing Date:Jun 29, 1993
Application Number:08/084,777
Claims:1. A method for assisting the restoration of periodontal tissue in a periodontal pocket, comprising:

placing a liquid mixture of a biodegradable, curable, thermosetting prepolymer, curing agent and a water-soluble material into the periodontal pocket;

wherein the water-soluble material dissipates into periodontal fluids, the thermosetting prepolymer cures in situ by formation of covalent bonds to form a water-immiscible thermoset polymer as a solid biodegradable implant, and the dissipation of the water-soluble material creates pores within the solid biodegradable implant having sizes in the range of about 3 to about 500 microns, the solid biodegradable implant having a porosity in the range of about 5 to 95 percent provided by the pores, and the sizes of the pores and porosity being effective to promote cell growth.

2. A method in accordance with claim 1, wherein said implant includes pores having a size in the range of 20 to 200 microns.

3. A method in accordance with claim 1, wherein said water-soluble material is selected from the group consisting of sugars, salts, and water-soluble polymers.

4. A method in accordance with claim 1, wherein said water-soluble material is present in an amount of about 5 to 85 percent by weight based upon the weight of said polymer.

5. A method in accordance with claim 1, wherein said implant further comprises a biologically active agent selected from the group consisting of antimicrobial agents, antibiotics and tissue repair mediators.

6. A method in accordance with claim 1, wherein said thermosetting prepolymer is an acrylic-ester-terminated prepolymer and a curing agent is added to said prepolymer prior to placing the mixture.

7. A method in accordance with claim 6, wherein said prepolymer comprises poly(DL-lactide-co-caprolactone).

8. A method for retarding apical migration of epithelial cells along a root surface of a tooth comprising placing a liquid mixture of a biodegradable, curable, thermosetting prepolymer, curing agent and water-soluble material into said periodontal pocket; wherein said water-soluble material dissipates into periodontal fluids and the curable thermosetting prepolymer cures in situ to form a water-immiscible thermoset polymer as a solid biodegradable barrier adjacent to said surface, and said dissipation of the water-soluble material creates pores within said solid biodegradable barrier having sizes in the range of about 3 to about 500 microns; said solid biodegradable barrier having porosity in the range of 5 to 95% provided by said pores; and the sizes of said pores and porosity being effective to promote cell growth.

9. A method in accordance with claim 8, wherein said thermosetting prepolymer is an acrylic-ester-terminated prepolymer and a curing agent is added to said prepolymer prior to placing the mixture.

10. A method in accordance with claim 9, wherein said prepolymer comprises poly(DL-lactide-co-caprolactone).

11. A method for promoting guided tissue regeneration in a periodontal pocket comprising: placing a liquid mixture of a biodegradable, curable, thermosetting prepolymer, curing agent and a water-soluble material into a periodontal pocket; wherein said water-soluble material dissipates into periodontal fluids and said thermosetting prepolymer cures in-situ to form a water-immiscible thermoset polymer as a solid biodegradable implant, and said dissipation of the water-soluble material creates pores within said solid biodegradable implant having sizes in the range of about 3 to 500 microns; said biodegradable implant having a porosity in the range of 5% to 95% provided by said pores; and the sizes of said pores and porosity being effective to create cell growth.

12. A method in accordance with claim 11, wherein said thermosetting prepolymer is an acrylic-ester-terminated prepolymer and a curing agent is added to said prepolymer prior to placing the mixture.

13. A method in accordance with claim 12, wherein said prepolymer comprises poly(DL-lactide-co-caprolactone).
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