|Title:||Use of 11,28-dioxa-4-azatricyclo[220.127.116.11.sup.4,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them|
|Abstract:||New use of 11,28-dioxa-4-azatricyclo[18.104.22.168.sup.4,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.|
|Inventor(s):||Grassberger; Maximilian (Vienna, AT), Meingassner; Josef G. (Perchtoldsdorf, AT), Stutz; Anton (Vienna, AT), Stutz; Peter (Vienna, AT)|
|Assignee:||Sandoz Ltd. (Basel, CH)|
|Filing Date:||Nov 30, 1992|
|Claims:||1. A method of topically treating psoriasis in a mammal in need of said treatment, which comprises administering topically to said mammal in an amount effective for the treament of psoriasis a compound of formula I: ##STR4## wherein R.sup.1 is optionally protected hydroxy, |
R.sup.2 is hydrogen or optionally protected hydroxy,
R.sup.3 is methyl, ethyl, propyl or allyl,
n is 1 or 2 and
the symbol of a line and dotted line is a single bond or a double bond,
in free form or in pharmacuetically acceptable salt form.
2. The method according to claim 1 in which the compound is: ##STR5## in free form or in pharmaceutically acceptable salt form.
3. A method according to claim 1 in which the compound is administered 2 to 5 times daily in the form of a lotion, gel, or cream comprising 1 to 3% of the compound.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.