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Serving leading biopharmaceutical companies globally:

US Department of Justice
US Army
Chinese Patent Office
Boehringer Ingelheim

Generated: December 16, 2017

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Title: Use of 11,28-dioxa-4-azatricyclo[,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them
Abstract:New use of 11,28-dioxa-4-azatricyclo[,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.
Inventor(s): Grassberger; Maximilian (Vienna, AT), Meingassner; Josef G. (Perchtoldsdorf, AT), Stutz; Anton (Vienna, AT), Stutz; Peter (Vienna, AT)
Assignee: Sandoz Ltd. (Basel, CH)
Filing Date:Nov 30, 1992
Application Number:07/982,925
Claims:1. A method of topically treating psoriasis in a mammal in need of said treatment, which comprises administering topically to said mammal in an amount effective for the treament of psoriasis a compound of formula I: ##STR4## wherein R.sup.1 is optionally protected hydroxy,

R.sup.2 is hydrogen or optionally protected hydroxy,

R.sup.3 is methyl, ethyl, propyl or allyl,

n is 1 or 2 and

the symbol of a line and dotted line is a single bond or a double bond,

in free form or in pharmacuetically acceptable salt form.

2. The method according to claim 1 in which the compound is: ##STR5## in free form or in pharmaceutically acceptable salt form.

3. A method according to claim 1 in which the compound is administered 2 to 5 times daily in the form of a lotion, gel, or cream comprising 1 to 3% of the compound.
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Serving leading biopharmaceutical companies globally:

Fish and Richardson
Chinese Patent Office
Cantor Fitzgerald
Farmers Insurance
Express Scripts

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