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Details for Patent: 5,336,506

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Details for Patent: 5,336,506

Title: Targeting of therapeutic agents using polysaccharides
Abstract:The invention relates to a method for the targeting of a therapeutic agent to a specific population of cells, wherein a complex is formed between the therapeutic agent and a polysaccharide capable of interacting with a cell receptor, and wherein the resulting complex is internalized into the cell by receptor mediated endocytosis (RME). In one embodiment of the invention, a complex of a therapeutic agent containing iron and the polysaccharide arabinogalactan may be formed and used to deliver iron specifically to hepatocytes by RME.
Inventor(s): Josephson; Lee (Arlington, MA), Groman; Ernest V. (Brookline, MA), Jung; Chu (Arlington, MA), Lewis; Jerome M. (Newton, MA)
Assignee: Advanced Magnetics Inc. (Cambridge, MA)
Filing Date:Aug 27, 1992
Application Number:07/936,873
Claims:1. A method for the targeting of a therapeutic agent to a selected population of cells capable of receptor mediated endocytosis (RME) comprising:

(i) forming a complex of the therapeutic agent with a polysaccharide molecule selected from the group consisting of arabinogalactan and hydrolyzed products thereof, the polysaccharide molecule being capable of interacting with an RME cell receptor; and

(ii) allowing the complex to be internalized into the selected population of cells by receptor mediated endocytosis.

2. A method according to claim 1, wherein the therapeutic agent includes a compound containing iron.

3. A method according to claim 1, wherein the therapeutic agent includes methotrexate.

4. A method according to claim 1, wherein the therapeutic agent includes an antiviral agent.

5. A method according to claim 4, wherein the therapeutic agent includes Ara A-phosphate.

6. A method according to claim 1, wherein the therapeutic agent includes trifluorthymidine.

7. A method according to claim 1, wherein the therapeutic agent includes a hormone.

8. A method according to claim 7, wherein the hormone includes a corticosteroid.

9. A method according to claim 7, wherein the hormone includes 6.alpha.-methylprednisolone.

10. A method according to claim 1, wherein the therapeutic agent includes a nucleic acid.

11. A method according to claim 1, wherein the therapeutic agent includes an enzyme.

12. A method according to claim 1, wherein the therapeutic agent includes a vitamin.

13. A method according to claim 12, wherein the vitamin is folic acid.
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