.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,334,381

« Back to Dashboard

Details for Patent: 5,334,381

Title: Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
Abstract:Liposomes suitable as ultrasound contrast agents which contain media of various types including gases, gaseous precursors activated by pH, temperature or pressure, as well as other solid or liquid contrast enhancing agents, are described. Methods of using the same as ultrasound contrast agents are also disclosed. The present invention also comprises novel methods for synthesizing liposomes having encapsulated therein gases.
Inventor(s): Unger; Evan C. (Tucson, AZ)
Assignee:
Filing Date:Jun 30, 1993
Application Number:08/085,608
Claims:1. A method for synthesizing a liposome having encapsulated therein a gas comprising contacting liposomes in an aqueous medium with gas under elevated pressures.

2. A method according to claim 1 wherein said pressure is between about 50 and about 120 psi.

3. A method according to claim 1 further comprising contacting said liposomes with gas under decreased temperature.

4. A method according to claim 3 wherein said decreased temperature is between about 1.degree. and about 4.degree. C.

5. A method according to claim 1 wherein said gas is selected from the group consisting of nitrogen, oxygen, carbon dioxide, xenon, argon, neon and helium.

6. A method according to claim 1 wherein said liposomes comprise egg phosphatidylcholine.

7. A method according to claim 5 wherein said gas is nitrogen.

8. A method according to claim 5 wherein said gas is oxygen.

9. A method according to claim 5 wherein said gas is carbon dioxide.

10. A method according to claim 5 wherein said gas is xenon.

11. A method according to claim 5 wherein said gas is argon.

12. A method according to claim 5 wherein said gas is neon.

13. A method according to claim 5 wherein said gas is helium.

14. A method according to claim 1 wherein said method further comprises contacting said liposomes with gas under decreased temperature, wherein said pressure is between about 50 and about 120 psi, and wherein said gas is selected from the group consisting of nitrogen, oxygen, carbon dioxide, xenon, argon, neon and helium.

15. The method according to claim 14 wherein said decreased temperature is between about 1.degree. and about 4.degree. C.

16. A method according to claim 15 wherein said gas is nitrogen.

17. A method according to claim 15 wherein said gas is oxygen.

18. A method according to claim 15 wherein said gas is carbon dioxide

19. A method according to claim 15 wherein said gas is xenon.

20. A method according to claim 15 wherein said gas is argon.

21. A method according to claim 15 wherein said gas is neon.

22. A method according to claim 15 wherein said gas is helium.

23. A method according to claim 15 wherein said liposomes comprise egg phosphatidylcholine.

24. A method according to claim 23 wherein said gas is nitrogen.

25. A method according to claim 23 wherein said gas is oxygen.

26. A method according to claim 23 wherein said gas is carbon dioxide.

27. A method according to claim 23 wherein said gas is xenon.

28. A method according to claim 23 wherein said gas is argon.

29. A method according to claim 23 wherein said gas is neon.

30. A method according to claim 23 wherein said gas is helium.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc