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Details for Patent: 5,334,375

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Details for Patent: 5,334,375

Title: Antibacterial antiplaque oral composition
Abstract:An oral composition containing a substantially water insoluble noncationic antibacterial antiplaque agent such as triclosan and a synthetic cross-linked polymer such as cross-linked poly (methylvinyl ether/maleic acid or anhydride) as antibacterial-enhancing agent to enhance delivery of said antibacterial agent to, and the retention thereof on, oral surfaces, and a method of promoting oral hygiene therewith.
Inventor(s): Nabi; Nuran (North Brunswick, NJ), Prencipe; Michael (East Windsor, NJ), Gaffar; Abdul (Princeton, NJ)
Assignee: Colgate Palmolive Company (Piscataway, NJ)
Filing Date:Jul 16, 1992
Application Number:07/914,083
Claims:1. An oral composition comprising in an orally acceptable vehicle an effective antiplaque amount of a substantially water insoluble noncationic antibacterial agent and an antibacterial-enhancing agent in an amount effective to enhance delivery of said antibacterial agent to, and the retention thereof on, oral surfaces, said antibacterial-enhancing agent comprising a synthetic cross-linked polymer having in a 1 wt.% aqueous solution an elastic or storage modulus G' and a viscous or loss modulus G' substantially independent of frequency in an applied frequency range of 0.1 to 100 radiants/sec., a G' minimum value of 5,000 dynes/sq. cm which varies less than 1 order of magnitude of its original value, and a ratio of G'/G' ranging from more than 0.05 to less than 1.

2. A composition according to claim 1 wherein said polymer has a molecular weight of about 1,000 to about 5,000,000.

3. A composition according to claim 2 wherein said polymer contains a plurality of carboxylic, phosphonic, phosphinic or sulfonic acid or acid salt groups or mixtures thereof.

4. A composition according to claim 3 wherein said polymer is made with a cross-linking agent containing at least two ethylenically unsaturated groups or at least two groups reactive with pendent reactive groups along the polymer chain.

5. A composition according to claim 4 wherein said polymer comprises a co-polymer of maleic acid or anhydride with another ethylenically unsaturated monomer.

6. A composition according to claim 5 wherein said other monomer comprises methyl vinyl ether.

7. A composition according to claim 6 wherein said copolymer is made with 1,7-octadiene, 1,9-decadiene, or polyethylene glycol as cross-linking agent.

8. A composition according to any of claims 1 to 7 wherein said antibacterial agent comprises a halogenated diphenyl ether, a halogenated salicylanilide, a benzoic ester, a halogenated carbanilide or a phenolic compound or any mixture thereof.

9. A composition according to any of claims 1 to 7 wherein said antibacterial agent comprises a halogenated diphenyl ether.

10. A composition according to claim 8 containing about 0.01 to about 5% of said antibacterial agent.

11. A composition according to claim 10 wherein said antibacterial agent comprises a halogenated diphenyl ether.

12. A composition according to claim 11 wherein said halogenated diphenyl ether comprises triclosan.

13. A composition according to any of claims 1 to 7 further containing an effective anticalculus amount of material comprising at least one linear molecularly dehydrated polyphosphate salt as anticalculus agent.

14. A composition according to claim 13 wherein said material comprises tetrasodium pyrophosphate, tetrapotassium pyrophosphate or a mixture thereof.

15. A composition according to claim 12 wherein said material comprises tetrasodium pyrophosphate, tetrapotassium pyrophosphate or a mixture thereof.

16. A composition according to anyone of claims 1 to 7 further containing an amount of a fluoride ion source sufficient to supply about 25 ppm to about 5,000 ppm of fluoride ions.

17. A composition according to claim 12 further containing an amount of a fluoride ion source sufficient to supply about 25 ppm to about 5,000 ppm of fluoride ions.

18. A composition according to claim 15 further containing an amount of a fluoride ion source sufficient to supply about 25 ppm to about 5,000 ppm of fluoride ions.

19. A composition according to anyone of claims 1 to 7 containing an amount of said cross-linked polymer effective to render the composition linearly viscoelastic.

20. A composition according to claim 12 containing an amount of said cross-linked polymer effective to render the composition linearly viscoelastic.

21. A composition according to claim 15 containing an amount of said cross-linked polymer effective to render the composition linearly viscoelastic.

22. A composition according to claim 18 containing an amount of said cross-linked polymer effective to render the composition linearly viscoelastic.

23. A composition according to any one of claims 1 to 7 in the form of a dentifrice containing a dentally acceptable polishing agent and a vehicle comprising water and humectant.

24. A composition according to claim 12 in the form of a dentifrice containing a dentally acceptable polishing agent and a vehicle comprising water and humectant.

25. A composition according to claim 15 in the form of a dentifrice containing a dentally acceptable polishing agent and a vehicle comprising water and humectant.

26. A composition according to claim 18 in the form of a dentifrice containing a dentally acceptable polishing agent and a vehicle comprising water and humectant.

27. A composition according to claim 22 in the form of a dentifrice containing a dentally acceptable polishing agent and a vehicle comprising water and humectant.

28. A method of promoting oral hygiene comprising applying to dental surface an effective amount of a composition as defined in any one of claims 1 to 7.

29. A method of promoting oral hygiene comprising applying to dental surface an effective amount of a composition as defined in claim 12.

30. A method of promoting oral hygiene comprising applying to dental surface an effective amount of a composition as defined in claim 15.

31. A method of promoting oral hygiene comprising applying to dental surface an effective amount of a composition as defined in claim 18.

32. A method of promoting oral hygiene comprising applying to dental surface an effective amount of a composition as defined in claim 22.

33. A method or promoting oral hygiene comprising applying to dental surface an effective amount of a composition as defined in claim 27.
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