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|Title:||Contrast media comprising a non-ionic contrast agent with low levels of sodium & calcium ions|
|Abstract:||The physiological acceptability of contrast media, especially media for use in angiography, may be enhanced by inclusion of sub-plasma levels of sodium and calcium and, optionally, potassium and/or magnesium, for example 30 mM Na, 0.15 mM Ca, 0.9 mM K and 0.1 mM Mg.|
|Inventor(s):||Almen; Torsten (Malmo, SE), Baath; Lars (Malmo, SE), Jynge; Per (Trondheim, NO), Oksendal; Audun N. (Oslo, NO)|
|Assignee:||Nycomed Imaging AS (Oslo, NO)|
|Filing Date:||Nov 06, 1992|
|Claims:||1. A contrast medium composition comprising a physiologically tolerable aqueous carrier medium with dissolved therein: a non-ionic contrast agent; a physiologically tolerable sodium compound providing a sodium ion concentration of 15 to 75 mM Na; a physiologically tolerable calcium salt providing a calcium ion concentration of 0.05 to 0.8 mM Ca; and optionally also at least one salt selected from physiologically tolerable potassium and magnesium salts, the total concentration of said 2 mM K; wherein the ratio of sodium to calcium ions is greater than 55. |
2. A composition as claimed in claim 1 containing calcium at a concentration of 0.05 to 0.7 mM Ca.sup.2+.
3. A composition as claimed in claim 1 containing calcium at a concentration of 0.1 to 0.6 mM Ca.sup.2+.
4. A composition as claimed in claim 1 and containing potassium at a concentration of 0.2 to 1.5 mM K.sup.+.
5. A composition as claimed in claim 1 and containing potassium at a concentration of 0.3 to 1.2 mM K.sup.+.
6. A composition as claimed in claim 1 containing magnesium at a concentration of up to 0.8 mM Mg.sup.2+.
7. A composition as claimed in claim 1 containing magnesium at a concentration of 0.05 to 0.4 mM Mg.sup.2+.
8. A composition as claimed in claim 1 containing an iodinated X-ray contrast agent.
9. A composition as claimed in claim 8 containing a contrast agent selected from iohexol, ioversol, iopamidol, iotrolan, ioxaglate and iodixanol.
10. A composition as claimed in claim 8 wherein sodium, calcium, potassium and magnesium are present at concentrations of 25-35 mM Na.sup.+, 0.1 to 0.3 mM Ca.sup.2+, 0.3 to 1.2 mM K.sup.+ and 0.05 to 0.2 mM Mg.sup.2+ and wherein, where said contrast agent is of ratio 6 or greater, said medium contains a further physiologically tolerable osmoactive agent.
11. A composition as claimed in claim 8 wherein sodium, calcium, potassium and magnesium are present at concentrations of 65-75 mM Na.sup.+, 0.3-0.6 mM Ca.sup.2+, 0.5-2.0 mM K.sup.+ and 0.1-0.4 mM Mg.sup.2+ and wherein said contrast agent is of ratio 6 or greater.
12. A composition as claimed in claim 1 having an osmolality of 290-320 mosm/kg H.sub.2 O.
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