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Details for Patent: 5,321,008

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Details for Patent: 5,321,008

Title: Methods and compositions for treatment of diabetes mellitus, hypoglycemia, and other conditions
Abstract:Methods for treatment of diabetes and other insulin-requiring conditions by administering insulin and a calcitonin with or without amylin, and methods for treatment of hypoglycemic conditions by administering a calcitonin alone or in combination with glucagon and/or an amylin, and related compositions.
Inventor(s): Beaumont; Kevin (San Diego, CA), Young; Andrew A. (San Diego, CA)
Assignee: Amylin Pharmaceuticals, Inc. (San Diego, CA)
Filing Date:Oct 10, 1991
Application Number:07/774,411
Claims:1. A method of treatment of diabetes mellitus, comprising the step of administering a therapeutically effective amount of an insulin and a calcitonin.

2. The method of claim 1 further comprising administering a therapeutically effective amount of an amylin.

3. The method of claim 1 wherein the ratio of insulin to said calcitonin is effective to achieve improved glycemic control over insulin therapy alone.

4. The method of claim 3 wherein said ratio of insulin to said calcitonin is from about 100:1 to about 1:2.

5. The method of claim 3 wherein said ratio of insulin to said calcitonin is from about 1:1 to about 20:1.

6. The method of claim 3 wherein said ratio of insulin to said calcitonin is about 10:1.

7. A method for the treatment of diabetes mellitus in an insulin-requiring mammal comprising administering to said mammal a therapeutically effective amount of a calcitonin.

8. The method of claim 7 wherein said calcitonin is selected from the group consisting of calcitonins of avian and teleost origin.

9. The method of claim 7 wherein said calcitonin is chicken calcitonin.

10. The method of claim 7 wherein said calcitonin is selected from the group consisting of eel calcitonin and salmon calcitonin.

11. The method of claim 7 wherein said mammal is a human.

12. The method of claim 11 wherein said human has type 1 diabetes mellitus.

13. The method of claim 4 wherein said human has type 2 diabetes mellitus.

14. The method of any of claims 7, 12 or 13 further comprising the step of administering a therapeutically effective amount of an amylin.
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