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|Title:||Process of optically resoluting optically active platinum complex compound|
|Abstract:||Disclosed herein is a process of optically resoluting optically active platinum complex compounds which comprises optically resoluting a d-isomer and an 1-isomer of a cis-Pt(II) complex of a 1,2-cyclohexanediamine isomer characterized in that the mixture of the d-isomer and the 1-isomer is optically resoluted by means of high performance liquid chromatography employing a column packed with a chiral filler. The chiral filler include, for example, a cellulose ester derivative, a cellulose carbamate derivative, an amylose carbamate derivative, a polymethacryl acid ester and .beta.- and .gamma.-cyclodextrin. According to the present invention, the optical resolution of a platinum complex compound essentially consisting of the mixture of two optical isomers which cannot be resoluted in accordance with a normal resolution method due to the small structural difference can be easily performed utilizing the characteristics of a chiral filler.|
|Inventor(s):||Tozawa; Takeshi (Kanagawa, JP), Komoda; Yasunobu (Kanagawa, JP), Ohnishi; Junji (Kanagawa, JP), Masuda; Yukie (Kanagawa, JP), Taniuchi; Junichi (Kanagawa, JP), Nakanishi; Chihiro (Kanagawa, JP), Okamoto; Koji (Kanagawa, JP)|
|Assignee:||Tanaka Kikinzoku Kogyo K.K. (JP)|
|Filing Date:||Apr 07, 1993|
|Claims:||1. A process of optically resoluting an optically active platinum complex compound which comprises optically resoluting a d-isomer and an 1-isomer of a cis-Pt(II) complex of a 1,2-cyclohexane-diamine isomer of Formula (3) [in this Formula, R designates one of Formulae (4), (5), (6), (7), (8) and (9)] characterized in that the mixture of the d-isomer and the 1-isomer is optically resoluted by means of high performance liquid chromatography employing a column packed with a chiral filler ##STR4## |
2. A process as claimed in claim 1, wherein the chiral filler is one or more fillers selected the group consisting of a cellulose ester derivative, a cellulose carbamate derivative, an amylose carbamate derivative, a polymethacryl acid ester, .beta.- and .gamma.-cyclodextrin, a polymethacrylamide derivative, an acidic glycoprotein, L-proline, hydroxyproline, L-valine, a filler prepared by adsorbing or binding (1R,2S)-2-carboxymethylamino-1,2-diphenylethanol to silica gel, a filler prepared by coordinating a metal ion to one of the said fillers, a filler prepared by adsorbing or binding a protein to aminated silica gel, a filler packed with a crown ether, a urea derivative chiral to silica gel treated with (3-aminopropyl)triethoxysilane, N(3,5-dinitrobenzoyl)-(R)-phenylglycine, DNB-L-leucine, (S)-1-(.alpha.-naphtyl)ethylamine and a filler chemically bonding to (S)-2-(4-chlorophenyl)isovaloric acid.
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