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Details for Patent: 5,296,214

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Details for Patent: 5,296,214

Title: Anticalculus composition
Abstract:An oral composition such as a dentifrice or mouth-wash, comprises an effective antiplaque amount of a substantially water-insoluble noncationic antibacterial agents, such as 2,4,4-trichloro-2'-hydroxy-diphenyl ether (Triclosan) and polyvinyl phosphonate antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to oral surfaces.
Inventor(s): Gaffar; Abdul (Princeton, NJ)
Assignee: Colgate-Palmolive Co. (New York, NY)
Filing Date:Aug 04, 1992
Application Number:07/925,363
Claims:1. An oral composition comprising an effective antiplaque amount of about 0.01%-5% of a substantially water insoluble noncationic antibacterial agent, 0.005%-4% by weight of polyvinyl phosphonate having recurring groups ##STR3## and average molecular weight of at least about 1,000 wherein M and M.sub.1 are hydrogen alkali metal or ammonium and wherein M and M.sub.1 are the same or different, and an orally acceptable vehicle comprising at least one of a surface-active agent or a flavoring oil effective to enable the said antibacterial agent to dissolve in saliva in effective antiplaque amount, said polyvinyl phosphonate enhancing the antibacterial effect of said antibacterial agent to inhibit plaque formation.

2. The oral composition claim in claim 1, in which the said oral composition is a dentifrice comprising about 5-30% by weight of a siliceous polishing agent and the said antibacterial agent is present in amount of about 0.25-0.35% by weight.

3. The oral composition claimed in claim 1, in which the said oral composition is a dentifrice comprising about 5-30% by weight of a siliceous polishing agent, the said antibacterial agent is present in amount of about 0.01-5% by weight and the said oral composition comprises a solubilizing material in amount to assist dissolving the said antibacterial agent in saliva.

4. The oral composition claimed in claim 3, in which the said antibacterial agent is present in amount of about 0.05% up to below about 0.25% by weight.

5. The oral composition claimed in claim 3, in which the said antibacterial agent is present in amount of above about 0.35% up to about 5% by weight.

6. The oral composition claimed in claim 5, in which the said antibacterial agent is present in amount of above about 0.35% up to about 0.5% by weight.

7. The oral composition claimed in any one of claims 1 to 6 in which the said oral composition is a dentifrice comprising about 30-75% by weight of a dentally acceptable water-insoluble polishing agent.

8. The oral composition claimed in claim 1, in which the said oral composition is a mouthwash or liquid dentifrice and the said orally acceptable vehicle is an aqueous vehicle wherein there is present a non-toxic alcohol.

9. The oral composition claimed 1 in which there is present surface-active agent in amount of about 0.5-5% by weight.

10. The oral composition claimed 1 in which there is present flavoring oil in amount of about 0.1-5% by weight.

11. The oral composition claimed in claim 8 in which the said composition is a mouthwash and the said aqueous vehicle contains ethanol and the weight ratio of water to ethanol is from about 1:1 to about 20:1.

12. The oral composition claimed in claim 8 or claim 11 in which the said oral composition is a liquid dentifrice containing about 0.3-2 0% by weight of a polysaccharide of high molecular weight in excess of 1,000,000 containing mannose, glucose, potassium glucuronate and acetyl moieties in the approximate ratio of 2:1:1:1, as suspending and thickening agent and about 10-20% by weight of a polishing material.

13. The oral composition claimed in any one of claims 1 to 12 in which the said antibacterial agent is selected form the group consisting of halogenated diphenyl ethers, halogenated salicylanilides, benzoic esters, halogenated carbanilides and phenolic compounds.

14. The oral composition claimed in claim 13 in which the said antibacterial agent is a halogenated diphenyl ether.

15. The oral composition claimed in claim 14 in which the said halogenated diphenyl ether is 2,4,4'-trichloro-2"-hydroxyphenyl ether.

16. The oral composition claimed in any one of claims 1 to 15 in which a solubilizing agent is present in amount of about 0.5 to 50% by weight and is selected from the group consisting of propylene glycol, dipropylene glycol, hexylene glycol, methyl cellosolve, ethyl cellosolve, vegetable oil and was containing at least about 12 carbon atoms, amyl acetate, ethyl acetate, glyceryl tristerate and benzyl benzoate.

17. The oral composition dentifrice claimed in claim 16 in which the solubilizing agent is propylene glycol and is present in amount of about 0.5% by weight.

18. The oral composition in the form of a dentifrice claimed claim 1 wherein about 30-70% by weight of a polishing agent is present which is selected from the group consisting of sodium metaphosphate, tri-calcium phosphate, dihydrated dicalcium phosphate, anhydrous dicalcium phosphate, anhydrous dicalcium phosphate, calcium pyrophosphate, magnesium orthophosphate, trimagnesium phosphate, calcium carbonate, aluminum silicate, hydrated alumina, silica, bentonite and mixtures thereof.

19. The oral composition dentifrice claimed in claim 18 wherein said polishing agent is dicalcium phosphate dihydrate or hydrated alumina.

20. The oral composition claimed in any one of claims 1 to 19 wherein said polyvinyl phosphonate has an average molecular weight of about 1,000 to about 1,000,000 and is present in amount of about 0.005-4% by weight.

21. The oral composition claimed in claim 20 in which the said PVPA copolymer has a molecular weight of about 6,000 to about 100,000.

22. The oral composition claimed in claim 21 in which said PVPA copolymer was a molecular weight of about 6,000 to about 8,000.

23. The oral composition claimed in claim 20 said polyvinyl phosphonate is present in amount of about 0.05-3% by weight.

24. A composition claimed in claim 23 in which said polyvinyl phosphonate is present in amount of about 0.1-2.5% by weight.

25. A method of inhibiting dental plaque comprising applying to tooth and soft gum surfaces the oral composition claimed in any one of claims 1 to 19.
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