.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,290,539

« Back to Dashboard

Details for Patent: 5,290,539

Title: Device for delivering an aerosol
Abstract:A device for delivering an aerosol, comprising: a casing member, a valve stem, and a diaphragm, wherein the diaphragm comprises a thermoplastic elastomer comprising a ethylene/1-butene copolymer. Also disclosed are sealing members comprising such an elastomer and thermoplastic polymer blends, e.g., for use in sealing members of the invention. The devices of the invention are particularly useful with formulations containing 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoropropane as the propellant.
Inventor(s): Marecki; Paul E. (May Township, Washington County, MN)
Assignee: Minnesota Mining and Manufacturing Company (St. Paul, MN)
Filing Date:Dec 18, 1991
Application Number:07/809,796
Claims:1. A device for delivering an aerosol, comprising: a valve stem, a diaphragm having walls defining a diaphragm aperture, and a casing member having walls defining a casing aperture, wherein the valve stem passes through the diaphragm aperture and the casing aperture and is in slidable sealing engagement with the diaphragm aperture, and wherein the diaphragm is in sealing engagement with the casing member, the diaphragm material comprising: a thermoplastic elastomer comprising a copolymer of about 80 to about 95 mole percent ethylene and a total of about 5 to about 20 mole percent of one or more comonomers selected from the group consisting of 1-butene, 1-hexene, and 1-octene.

2. A device according to claim 1, wherein the sole comonomer is 1-butene.

3. A device according to claim 1, wherein the sole comonomer is 1-hexene.

4. A device according to claim 1, wherein the sole comonomer is 1-octene.

5. A device according to claim 1, wherein the thermoplastic elastomer comprises a copolymer of about 91 mole percent ethylene and about 9 mole percent 1-butene.

6. A device according to claim 1, wherein the thermoplastic elastomer comprises a copolymer of about 88 mole percent ethylene and about 12 mole percent 1-butene.

7. A device according to claim 1, wherein the thermoplastic elastomer comprises a copolymer of about 80 mole percent ethylene and about 20 mole percent 1-butene.

8. A device according to claim 1, wherein the thermoplastic elastomer comprises a copolymer of about 90 mole percent ethylene and about 10 mole percent 1-butene.

9. A device according to claim 1, wherein the thermoplastic elastomer comprises a copolymer of about 92 mole percent ethylene and about 8 mole percent 1-butene.

10. A device according to claim 1, wherein the thermoplastic elastomer comprises a copolymer of about 90 mole percent ethylene and about 10 mole percent 1-octene.

11. A device according to claim 1, wherein the thermoplastic elastomer comprises a copolymer of about 92 mole percent ethylene and about 8 percent 1-octene.

12. A device according to claim 1, wherein the thermoplastic elastomer comprises a copolymer of about 95 mole percent ethylene, about 1 mole percent 1-butene, and about 4 mole percent 1-hexene.

13. A device according to claim 1, wherein the thermoplastic elastomer comprises a copolymer of about 94 mole percent ethylene, about 1 mole percent 1-butene, and about 5 mole percent 1-octene.

14. A device according to claim 1, wherein the thermoplastic elastomer is a thermoplastic polymer blend comprising at least two thermoplastic copolymers, each comprising a copolymer of about 80 to about 95 mole percent ethylene and a total of about 5 to about 20 mole percent of one or more comonomers selected from the group consisting -butene, 1-hexene, and 1-octene.

15. A device according to claim 14, wherein the sole comonomer in each of the copolymers is 1-butene.

16. A device according to claim 14, wherein the thermoplastic polymer blend comprises (i) a copolymer of about 91 mole percent ethylene and about 9 mole percent 1-butene, and (ii) a copolymer of about 80 mole percent ethylene and about 20 mole percent 1-butene.

17. A device according to claim 16, wherein the thermoplastic polymer blend comprises one part by weight of component (i) and about 0.25 to about 4 parts by weight of component (ii).

18. A device according to claim 1, wherein the casing member defines a formulation chamber.

19. A device according to claim 18, wherein the formulation chamber contains an aerosol formulation comprising 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, or a mixture thereof, in an amount effective to function as a propellant.

20. A device according to claim 19, wherein the formulation is a pharmaceutical formulation comprising 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, or a mixture thereof, in an amount effective to function as an aerosol propellant, and a drug in an amount sufficient to provide a predetermined number of therapeutically effective doses for inhalation.

21. A device according to claim 20, wherein the drug is a bronchodilator or a steroid.

22. A device according to claim 20, wherein the drug is albuterol sulfate.

23. A device according to claim 20, wherein the drug is beclomethasone dipropionate.

24. A device according to claim 20, wherein the drug is pirbuterol acetate.

25. A device according to claim 19, wherein the formulation further comprises ethanol.

26. A device according to claim 25, wherein the formulation further comprises oleic acid.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc