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|Title:||Methods of treating tumors with compositions of catecholic butanes|
|Abstract:||The invention relates to methods useful in the treatment of benign, premalignant and malignant solid tumors, especially those of the skin comprising methods for the administration of pharmacologically active compositions containing catecholic butanes. The invention also relates to methods of preventing the occurrence of tumors, and the use of catecholic butanes as a sunscreening agent. The preferred catecholic butane is nordihydroguaiaretic acid. The preferred methods of application of the compositions containing catecholic butanes are by topical application and intratumor injection.|
|Inventor(s):||Neiss; Edward S. (Denver, CO), Allen; Larry M. (Golden, CO), Jordan; Russell T. (Fort Collins, CO)|
|Assignee:||Block/Chemex, G.P. (Jersey City, NJ)|
|Filing Date:||Apr 15, 1991|
|Claims:||1. A method for treating warts which comprises administering to a mammal in need of said treatment an effective amount of a composition comprising at least one catecholic butane of the formula: ##STR3## wherein R.sub.1 and R.sub.2 are independently H, lower alkyl, lower acyl, or alkylene provided that when R.sub.1 is H R.sub.2 is not H; |
R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.10, R.sub.11, R.sub.12 and R.sub.13 are independently H or lower alkyl; and
R.sub.7, R.sub.8 and R.sub.9 are independently H, hydroxy, lower alkoxy, lower acyloxy, or any two adjacent groups together may be alkylene dioxy.
2. A method for treating warts comprising administering to a mammal in need of said treatment an effective amount of a composition comprising nordihydroguairetic acid.