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Details for Patent: 5,273,741

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Details for Patent: 5,273,741

Title: Packaged anti-plaque oral compositions
Abstract:An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container or bottle which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. Also described is a method for inhibiting development of plaque on teeth.
Inventor(s): Gaftar; Abdul (Princeton, NJ), Robinson; Richard S. (Piscataway, NJ), Miller; Jeffrey (Sayreville, NJ), Potini; Chimpiramma (Brunswick, NJ), Collins; Michael A. (Keyport, NJ), Shackil; Theresa G. (Vincentown, NJ)
Assignee: Colgate-Palmolive Company (New York, NY)
Filing Date:Jul 30, 1992
Application Number:07/922,252
Claims:1. A method of inhibiting plaque on teeth comprising applying to the teeth an oral composition dispensed from an article comprising a dispensing container having solid polyethylene or polyethylene terephthalate polymeric material in contact with said oral composition in the container, which composition comprises an effective antibacterial antiplaque proportion of a substantially water insoluble noncationic halogenated diphenyl ether antibacterial antiplaque agent and a stabilizer to make said polymeric material compatible with said agent in the presence of the oral composition, which compatibility is such that after three weeks storage at elevated temperatures of at least about 41.degree. C. less than about 25% of said agent is lost.

2. A method according to claim 1 in which the composition is a toothpaste, gel or liquid dentifrice, a liquid mouthwash, or a paste, gel or liquid tooth treating agent and in which the container is a deformable dispensing tube, a pump dispenser, a pressurized dispenser, or a sachet for toothpaste, gel dentifrice, or paste or gel tooth treating agent, or a bottle or other container for a liquid dentifrice, mouthwash or tooth treating agent.

3. A method according to claim 2 in which the composition is a toothpaste, gel dentifrice or liquid mouthwash, and wherein the halogenated diphenyl ether antibacterial agent comprises a diphenyl ether substituted with 1-3 hydroxyls and 1-4 halogens selected from the group consisting of chlorine and bromine, and in which the container is a deformable dispensing tube, a pump dispenser or a sachet for the toothpaste or gel dentifrice or is a bottle or other dispensing container for the liquid mouthwash.

4. A method according to claim 1 wherein the halogenated diphenyl ether antibacterial agent comprises 2',4,4'-trichloro-2-hydroxy-diphenyl ether (THDE) or 2,2'-dihydroxy-5,5'-dibromodiphenyl ether (DDDE).

5. A method according to claim 4 wherein the halogenated diphenyl ether antibacterial agent comprises THDE.

6. A method according to claim 4 in which the composition comprises 0.02 to 1% of THDE and/or DDDE.

7. A method according to claim 4 in which the composition comprises 0.02 to 1% of THDE.

8. A method according to claim 4 in which the composition is a liquid mouthwash containing 0.03 to 0.1% of THDE and wherein the solid polymeric material in contact with the oral composition in the container comprises polyethylene.

9. A method according to claim 4 in which the composition is a toothpaste or gel dentifrice containing 0.25 to 0.5% of THDE in a deformable dispensing tube, a pump dispenser or a sachet and the solid polymeric material in contact with the oral composition in the container comprises polyethylene.

10. A method according to claim 4 in which composition is a toothpaste or gel dentifrice containing about 0.3% of THDE and the container is a deformable dispensing tube or a pump dispenser.

11. A method according to claim 1 wherein the solid polymeric material which contacts the oral composition, comprises polyethylene.

12. A method according to claim 1 wherein the solid polymeric material in contact with the oral composition comprises polyethylene terephthalate.

13. A method according to claim 1 in which the composition contains a stabilizing proportion of a terpene or flavoring agent as the stabilizer.

14. A method according to claim 8 wherein the liquid mouthwash contains a stabilizing 0.01 to 2% proportion of terpene or flavoring agent as the stabilizer.

15. A method according to claim 9 wherein the toothpaste or gel dentifrice contains a stabilizing 0.01 to 2% proportion of terpene or flavoring agent.

16. A method according to claim 13 wherein said polymeric material comprises polyethylene.

17. A method according to claim 13 wherein said polymeric material comprises polyethylene terephthalate.

18. A method according to claim 13 wherein the terpene content of the stabilizer is about 0.01 to about 2% of the composition.

19. A method according to claim 16 wherein the terpene content of the stabilizer is about 0.01 to about 2% of the composition.

20. A method according to claim 13 wherein the terpene content of the stabilizer is about 0.1 to about 0.5% of the composition.

21. A method according to claim 13 wherein the terpene comprises limonene.

22. A method according to claim 1 in which the composition comprises about 0.5 to 4% of polyvinyl methyl ether maleic anhydride copolymer.

23. A method according to claim 1 in which the composition comprises a tooth hardening proportion of fluoride ions and an antitartar proportion of a polyphosphate or a mixture of polyphosphates.

24. A method according to claim 23 in which the composition comprises fluoride ions and about 0.5 to 4% of polyvinyl methyl ether maleic anhydride copolymer which together stabilize the polyphosphate(s) against enzymatic loss of anti-tartar action.

25. A method according to claim 1 wherein said container is opaque.
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