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Details for Patent: 5,256,137

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Details for Patent: 5,256,137

Title: Biphasic power source for use in an iontophoretic drug delivery system
Abstract:A biphasic power source for use in an iontophoretic system, which system includes a transdermal drug delivery device attachable to a patient and having a positive electrode and a negative electrode, includes a constant current source and a voltage limiting circuit. The constant current source has two outputs and provides a constant current on the outputs. The outputs are connected to the positive and negative electrodes of the transdermal drug delivery device. The voltage limiting circuit is connected in parallel with the outputs of the constant current source to limit the voltage across the electrodes to a predetermined voltage. The voltage limiting circuit may be a zener diode.
Inventor(s): Sage, Jr.; Burton H. (Raleigh, NC)
Assignee: Becton Dickinson and Company (Franklin Lakes, NJ)
Filing Date:Mar 10, 1992
Application Number:07/848,217
Claims:1. An iontophoresis system for delivering therapeutic compounds to the skin of an animal, which comprises:

a transdermal drug delivery device attachable to the animal and in communication with the skin thereof, the device including a first electrode and a second electrode, and reservoirs for containing an electrolyte and a therapeutic drug in electrical communication with the first and second electrodes;

a biphasic power source connected to the first and second electrodes of the drug delivery device, the biphasic power source including means for providing a constant voltage, and means for providing a constant current, the constant current means and constant voltage means being connected to the electrodes of the drug delivery device;

means for switching between said constant voltage providing means and said constant current providing means when the skin impedance of the animal is less than a predetermined level;

wherein the biphasic power source is in a first mode and supplying a constant voltage to the first and second electrodes when the skin impedance of the animal is at least equal to a predetermined level, and wherein the biphasic power source is in a second mode and supplying a constant current to the first and second electrodes when the skin impedance of the animal is less than the predetermined level.

2. An iontophoresis system as defined by claim 1, wherein the constant voltage means limits the voltage across the first and second electrodes to between about 3 and about 30 volts.

3. An iontophoresis system as defined by claim 1, wherein the constant voltage means limits the voltage across the first and second electrodes to between about 6 and about 20 volts.

4. An iontophoresis system as defined by claim 1, wherein the means for providing a constant voltage includes a zener diode, and the first electrode is a positive electrode and the second electrode is a negative electrode, and wherein the zener diode has an anode connected to the negative electrode and a cathode connected to the positive electrode.

5. An iontophoresis system as defined by claim 4, wherein the zener diode is selected to have a breakdown voltage of between about 3 and about 30 volts.

6. An iontophoresis system as defined by claim 4, wherein the zener diode is selected to have a breakdown voltage of between about 6 and about 20 volts.

7. A method for providing power to electrodes of a transdermal drug delivery device attachable to the skin of an animal, the method comprising the steps of:

supplying a constant voltage to the electrodes of the transdermal drug delivery device when the skin impedance of the animal is at least equal to a predetermined level; and

supplying a constant current to the electrodes when the skin impedance of the animal is less than the predetermined level.
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