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Details for Patent: 5,234,688

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Details for Patent: 5,234,688

Title: Anti-plaque dentifrice packaged in resilient squeezable form maintaining dispensing container
Abstract:A dental composition, such as a paste or gel dentifrice containing triclosan, as an antibacterial agent which acts to decrease plaque on the teeth, is packaged in a hand holdable and squeezable dispensing container which is made of or includes a part or parts of a solid polymeric material, such as a polyfluoroethylene or polyvinyl chloride, which is compatible with triclosan, so that excessive loss of its anti-plaque activity on storage is avoided, which losses have been noted when various other plastics have been employed as dispensing container component materials. Alternatively, other more reactive plastics may be employed for such dispensing container parts when a stabilizer, such as terpene, e.g., limonene, is present in the dentifrice. The dentifrice preferably also contains an anti-tartar proportion of polyphosphate, a tooth hardening proportion of a source of fluoride ions, a stabilizing proportion (in conjunction with the fluoride source) for the polyphosphate, of a polyvinyl methyl ether/maleic anhydride copolymer, and normal dentifrice components and adjuvants.
Inventor(s): Gaffar; Abdul (Princeton, NJ)
Assignee: Colgate-Palmolive Company (Piscataway, NJ)
Filing Date:Jul 02, 1990
Application Number:07/547,642
Claims:1. An article comprising a viscous anti-plaque, anti-tartar dentifrice comprising 0.1 to 1% of triclosan, 0.1 to 3% of polyphosphate and 0.01 to 2% of a stabilizing terpene which stabilizes the triclosan in the presence of synthetic organic polymeric plastic container parts, in a form-maintaining resilient squeezable dispensing container which has a walled dispensing chamber, in which container parts thereof that contact the dentifrice during storage and during dispensing thereof comprise polyethylene terephthalates, poly-lower alkylenes or pluralities thereof.

2. An article comprising a form-maintaining resilient squeezable dispensing container having solid destabilizing polyethylene or polyethylene terephthalate polymeric material in contact with a viscous anti-plaque, anti-tartar dentifrice in the dispenser, which dentifrice comprises an effective anti-plaque proportion of a halogenated diphenyl ether and a stabilizing proportion of a terpene which stabilizes the halogenated diphenyl ether in the presence of said destabilizing material.

3. An article according to claim 2 wherein said destabilizing material comprises polyethylene, said halogenated diphenyl ether comprises triclosan and said terpene comprises limonene.

4. An article comprising a hand holdable resilient squeezable form-maintaining dispensing container having solid polyethylene or polyethylene terephthalate polymeric material in contact with a dentifrice composition in the container, which composition comprises an effective antibacterial antiplaque proportion of a substantially water insoluble non-cationic halogenated diphenylether antibacterial antiplaque agent, at least about 25% of which has been found to be lost after twelve weeks storage at room temperature in said container, and a stabilizing terpene to make said polymeric material compatible with said agent in the presence of the oral composition whereby said loss is prevented and the dispensed composition contains more than about 75% of its initial content of said agent.

5. An article according to claim 4 wherein the stabilizing terpene is not a component of a flavoring agent.

6. An article according to claim 1 wherein the stabilizing terpene is not a component of a flavoring agent.

7. An article according to claim 4 wherein the dentifrice is in paste or gel form.

8. An article according to claim 4 in which the dentifrice comprises 0.1 to 1% of triclosan.

9. An article according to claim 4 in which the dentifrice comprises an effective anti-tartar proportion of synthetic linear molecularly dehydrated polyphosphate antitartar agent.

10. An article according to claim 9 in which the dentifrice comprises 0.1 to 3% of said polyphosphate antitartar agent.

11. An article according to claim 4 in which the dentifrice comprises an effective proportion of an antibacterial enhancing agent (AEA) which comprises a synthetic anionic polymeric polycarboxylate.

12. An article according to claim 11 wherein the AEA comprises methyl vinyl ether/maleic anhydride copolymer of average molecular weight in the range of 1,000 to 1,000,000.

13. An article according to claim 4 in which the dentifrice comprises an effective proportion of a source of fluorine ion sufficient to stabilize the polyphosphate against enzymatic hydrolysis.

14. An article according to claim 13 wherein the source of fluorine ion comprises 0.005 to 3% of an inorganic fluoride or monofluorophosphate.

15. An article according to claim 4 in which the dentifrice is an aqueous paste or gel or mixture thereof, which comprises a vehicle, a polishing gent, a surfactant and triclosan, and the container comprises a walled resilient tube, a flexible bag or liner, a bottom for such tube, an air check valve to prevent passage of air out from between the bag and the tube, near the bottom thereof, during squeezing of the package, and to permit entrance of air during resilient return of the tube to normal shape after release of squeezing forces, a dispensing passageway and an outlet, with the passageway communicating the dentifrice in the bag or liner with the outlet, and dentifrice suckback limiting means between the dispensing outlet and the flexible bag, which limit entry of air into the dispensing container through the outlet and thereby prevent belching of air from the dispensing container during use thereof.

16. An article according to claim 15 in which the dentifrice comprises 0.2 to 0.8% of triclosan, 0.5 to 3% of polyphosphate antitartar agent, 0.005 to 3% of a source of fluorine ions and 0.2 to 5% of synthetic anionic polymeric polycarboxylate, and in the squeezable dispensing container the portion of the bag or liner that contacts the dentifrice comprises polyethylene.

17. An article according to claim 16 wherein the bag or liner is a laminate which includes a non-contacting barrier layer of metal.

18. An article according to claim 4 in which the dentifrice comprises 0.01 to 2% of stabilizing terpene(s).

19. An article according to claim 4 in which the dentifrice is an aqueous paste or gel or mixture thereof, which comprises a vehicle, a polishing agent, a surfactant and triclosan, and the container comprises a walled resilient tube, a flexible bag or liner, a bottom for such tube, an air check valve to prevent passage of air out from between the bag and the tube, near the bottom thereof, during squeezing of the tube, and to permit entrance of air during resilient return of the tube to normal shape after release of squeezing forces, a dispensing passageway and an outlet, with the passageway communicating the dentifrice int he bag or liner with the outlet, and dentifrice suckback limiting means between the dispensing outlet and the flexible bag, which limit entry of air into the dispensing container through the outlet and thereby prevent belching of air from the dispensing container during use thereof.

20. An article according to claim 19 wherein the dentifrice comprises 0.1 to 1% of triclosan.

21. An article according to claim 19 wherein the dentifrice comprises 0.1 to 3% of synthetic linear molecularly dehydrated polyphosphate.

22. An article according to claim 19 wherein the dentifrice comprises 0.05 to 1% of a source of fluorine ions.

23. An article according to claim 19 wherein the dentifrice comprises 0.2 to 5% of synthetic anionic polymeric polycarboxylate.

24. An article according to claim 19 wherein the dentifrice comprises 0.1 to 1% of triclosan, 0.1 to 3% tetrasodium pyrophosphate, sodium tripolyphosphate or sodium hexametaphosphate or any mixture thereof, 0.05 to 1% of sodium fluoride or sodium monofluorophosphate or a mixture thereof, 0.2 to 5% of polyvinyl methyl ether/maleic anhydride copolymer, and 0.05 to 1% of stabilizing terpene(s).

25. An article according to claim 24 wherein the portion of the bag or liner that contacts the dentifrice comprises polyethylene.

26. An article according to claim 25 wherein the bag or liner comprises a laminate of polyethylene and polyethylene terephthalate.

27. An article according to claim 26 wherein the bag or liner laminate has an aluminum coating between polyethylene and polyethylene terephthalate laminate.
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