Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

US Department of Justice
UBS
US Army
Cipla
Express Scripts
Cerilliant
Argus Health
Citi
Daiichi Sankyo
Deloitte

Generated: August 20, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title: Lyophilized cyclophosphamide
Abstract:A lyophilized pharmaceutical solid composition containing cyclophosphamide for reconstitution with water to provide a solution for oral or parenteral administration. This lyophilized cyclophosphamide solid composition demonstrates improved stability, solubility characteristics and enhanced appearance compared with currently available dry powder pre-mix compositions of cyclophosphamide. The lyophilized solid composition contains about 20 parts by weight of cyclophosphamide, about 11/4-2 parts by weight of water and from about 10-85 parts by weight of excipient which is comprised mainly of mannitol. Processes for making the composition are disclosed.
Inventor(s): Alexander; Robert L. (Evansville, IN), Bequette; Robert J. (Evansville, IN), Kensler; Terry T. (Evansville, IN), Scott; Joseph A. (Evansville, IN)
Assignee: Mead Johnson & Company (Evansville, IN)
Filing Date:Dec 23, 1991
Application Number:07/812,155
Claims:1. A hydrated lyophilizate composition for reconstitution with water with improved stability and enhanced appearance comprising about 100 parts by weight of cyclophosphamide, taken as the anhydride, from about 61/4 to about 10 parts by weight of water and from about 50 to about 75 parts by weight of sodium bicarbonate.

2. A hydrated lyophilizate composition for reconstitution with water with improved stability and enhanced appearance comprising cyclosphosphamide, sodium bicarbonate in an amount sufficient to form a lyophilized cake retaining its original shape and capable of easy dissolution on reconstitution with water, and which has been rehydrated in order to impart improved thermal stability to the cyclophosphamide.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

AstraZeneca
Fish and Richardson
Cerilliant
Queensland Health
US Army
Boehringer Ingelheim
UBS
Cipla
Harvard Business School
Deloitte

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot