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Generated: April 20, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,206,364

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Title: Triazole antifungal agents
Abstract:The invention provides antifungal agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and CF.sub.3 ; R.sup.1 is C.sub.1 -C.sub.4 alkyl; R.sup.2 is H or C.sub.1 -C.sub.4 alkyl; and "Het", which is attached to the adjacent carbon atom by a ring carbon atom, is selected from pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl, "Het" being optionally substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, CN, NO.sub.2, NH.sub.2, --NH(C.sub.1 -C.sub.4 alkanoyl) or --NHCO.sub.2 (C.sub.1 -C.sub.4 alkyl).
Inventor(s): Dickinson; Roger P. (Dover, GB2), Richardson; Kenneth (Birchington, GB2)
Assignee: Pfizer Inc. (New York, NY)
Filing Date:Mar 04, 1992
Application Number:07/845,986
Claims:1. A compound of the formula ##STR41## or a pharmaceutically acceptable acid addition salt thereof, wherein R is chlorophenyl, fluorophenyl, dichlorophenyl or difluorophenyl; R.sup.1 is alkyl having one to four carbon atoms; R.sup.2 is hydrogen or alkyl having one to four carbon atoms; and Het is triazinyl, optionally substituted with a fluoro, chloro, bromo, alkyl having from one to four carbon atoms, alkoxy having from one to four carbon atoms, trifluoromethyl, nitro, alkanoylamino having one to four carbon atoms, alkoxycarbonylamino having two to five carbon atoms, amino or cyano group.

2. A compound of claim 1, wherein R.sup.1 is methyl and R.sup.2 is hydrogen.

3. A compound of claim 1, wherein the stereoconfiguration is ##STR42##

4. A compound of claim 3, wherein R.sup.1 is methyl and R.sup.2 is hydrogen.

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Cipla
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