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Details for Patent: 5,178,851

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Details for Patent: 5,178,851

Title: Antiplaque antibacterial oral composition
Abstract:An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, about 0.25-0.35% by weight of a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan) and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
Inventor(s): Gaffar; Abdul (Princeton, NJ), Nabi; Nuran (N. Brunswick, NJ), Afflitto; John (Brookside, NJ), Stringer; Orum (Yardley)
Assignee: Colgate-Palmolive Company (Piscataway, NJ)
Filing Date:Feb 14, 1991
Application Number:07/655,571
Claims:1. In a method for attaching, adhering or bonding a plaque-inhibiting antibacterial agent to oral tooth and gum surfaces which comprises introducing into contact with tooth and gum surfaces in the oral cavity an oral composition dentifrice comprising an orally acceptable aqueous vehicle, about 5-30% by weight of a siliceous polishing agent, about 0.25%-0.35% by weight of a substantially water insoluble noncationic antibacterial agent, said oral composition dentifrice comprising at least one of a surface active-agent and a flavoring oil, the improvement which comprises employing in said composition an effective amount of about 0.05-4% by weight of a water-soluble or swellable antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces, wherein said oral composition dentifrice is free of polyphosphate anticalculus agent in an effective anticalculus amount.

2. In a method of preparing an oral composition dentifrice wherein delivery and retention of a plaque-inhibiting antibacterial agent is enhanced by attaching, adhering or bonding to oral tooth and gum surfaces comprising an orally acceptable aqueous vehicle, about 5-30% by weight of a siliceous polishing agent, about 0.25%-0.35% by weight of a substantially water insoluble noncationic antibacterial agent, said oral composition dentifrice comprising at least one of a surface active-agent and a flavoring oil, the improvement comprising employing in said composition an effective amount of about 0.05-4% by weight of a water-soluble or swellable antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said anti-bacterial agent on oral tooth and gum surfaces, wherein said oral composition dentifrice is free of polyphosphate anticalculus agent in an effective anticalculus amount.

3. The method claimed in either of claims 1 or 2 wherein said anti-bacterial agent is a halogenated diphenyl ether.

4. The method claimed in claim 3 wherein said halogenated diphenyl ether is 2,4,4'-trichloro-2'-hydroxydiphenyl ether.

5. The method claimed in either of claims 1 or 2 wherein said surface active agent is present in amount of about 0.5-5% by weight.

6. The method claimed in either of claims 1 or 2 wherein said flavoring oil is present in amount of about 0.1-5% by weight.

7. The method claimed in either of claims 1 or 2 wherein said antibacterial-enhancing agent has an average molecular weight of about 100 to about 1,000,000.

8. The method claimed in claim 7 wherein said delivery-enhancing group is acidic.

9. The method claimed in claim 8 wherein said delivery-enhancing group is selected from the group consisting of carboxylic, phosphonic, phosphinic, and sulfonic acids, and their salts, and mixtures thereof and wherein said organic retention-enhancing group comprises the formula --(X).sub.n --R wherein X is O, N, S, SO, So.sub.2, P, PO or Si, R is hydrophobic alkyl, alkenylene, acyl, aryl, alkaryl, aralkyl, heterocyclic, or their inert-substituted derivatives, and n or zero or one or more.

10. The method claimed in claim 9 wherein said antibacterial-enhancing agent is an anionic polymer containing a plurality of said delivery-enhancing and retention-enhancing groups.

11. The method claimed in claim 10 wherein said anionic polymer comprises a chain containing repeating units each containing at least one carbon atom.

12. The method claimed in claim 11 wherein each unit contains at least one delivery-enhancing group bonded to the same, vicinal, or other atoms in the chain.

13. The method claimed in claim 9 wherein the delivery-enhancing group is a carboxylic group of salt thereof.

14. The method claimed in either of claims 1 or 2 wherein said oral composition contains an effective anticaries amount of a fluoride ion-providing source.
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