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Details for Patent: 5,171,812

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Details for Patent: 5,171,812

Title: Polyanhydrides of oligomerized unsaturated aliphatic acids
Abstract:A polyanhydride suitable for use as a matrix material in controlled delivery devices polymerized from monomers of the general formula: ##STR1## wherein R, R', and R" are the same or a different aliphatic chain of C.sub.1 to C.sub.20 or hydrogen; m, n, and p are integers from 0 and 20; y is 0 or 1; and, if y is 0, one of R or R' is not H.
Inventor(s): Domb; Abraham J. (Baltimore, MD)
Assignee: Nova Pharmaceutical Corporation (Baltimore, MD)
Filing Date:Jan 19, 1990
Application Number:07/467,635
Claims:1. A polyanhydride polymerized from monomers of the group consisting of dimers and trimers of unsaturated fatty acids and dimers and trimers of non-naturally occurring unsaturated aliphatic acids.

2. The polyanhydride of claim 1 wherein the monomer is selected from the group consisting of dimers and trimers of naturally occurring unsaturated fatty acids.

3. The polyanhydride of claim 2, wherein the monomer is selected from the group consisting of dimers and trimers of oleic, erucic, lauroleic, myristoleic, gadoleic, ricinoleic, palmitoleic, linoleic, linolenic, and arachidonic acids.

4. The polyanhydride of claim 1, wherein the monomer is selected from the group consisting of dimers and trimers of non-naturally occurring unsaturated aliphatic acids.

5. The polyanhydride of claim 4, wherein the monomer is selected from the group consisting of dimers and trimers of acrylic, methacrylic, fumaric, crotonic, vinyl acetic (3-butenoic), isocrotonic, allylacetic (4-pentenoic), hexenoic and undecylenic acids.

6. The polyanhydride of claim I comprising an aliphatic dicarboxylic acid selected from the group consisting of sebacic acid, isophthalic acid, adipic acid, 1,10-dodecanoic acid, or 1,3 bis(p-carboxyphenoxypropane).

7. The polyanhydride of claim 1 that is soluble in organic solvents.

8. The polyanhydride of claim 1 that has a melting point below 65.degree. C.

9. The polyanhydride of claim 1 that is strong and flexible.

10. The polyanhydride of claim 1 prepared by melt polycondensation.

11. The polyanhydride of claim 1 prepared by solution polymerization.

12. The polyanhydride of claim prepared by solvent casting.

13. The polyanhydride of claim 1 prepared by melt casting.
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