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Details for Patent: 5,169,857

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Details for Patent: 5,169,857

Title: 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
Abstract:Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings, X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, and R is ##STR2## wherein R.sup.21 denotes hydrogen or alkyl and R.sup.22 denotes hydrogen, deontes alkyl, aryl or aralkyl, or denotes a cation, and their oxidation products.
Inventor(s): Angerbauer; Rolf (Wuppertal, DE), Fey; Peter (Wuppertal, DE), Hubsch; Walter (Wuppertal, DE), Philipps; Thomas (Cologne, DE), Bischoff; Hilmar (Wuppertal, DE), Petzinna; Dieter (Duesseldorf, DE), Schmidt; Delf (Wuppertal, DE), Thomas; Gunter (Arese, IT)
Assignee: Bayer Aktiengesellschaft (Leverkusen, DE)
Filing Date:Dec 13, 1990
Application Number:07/627,086
Claims:1. A substituted pyridine of the formula ##STR233## in which B and E are C.sub.1-3 -alkyl of which one may be cyclopropyl, Y--Q--is ##STR234## R.sup.22 is hydrogen, lower alkyl, phenyl, benzyl or a physiologically tolerable metal or ammonium cation, and

Z is F, CH.sub.3 or OCH.sub.3.

2. A substituted pyridine according to claim 1 of the formula ##STR235##

3. A substituted pyridine of the formula ##STR236## in which B and E are C.sub.1-3 -alkyl of which one may be cyclopropyl,

W is Y--Q--CH.sub.2 or CN, Y--Q--is CH.sub.3 O--, (H.sub.3 C).sub.3 C(CH.sub.3).sub.2 --Si--O--, ##STR237## R.sup.22 is hydrogen, lower alkyl, phenyl, benzyl or a physiologically tolerable metal or ammonium cation, and

Z is F, CH.sub.3 or OCH.sub.3.

4. A substituted pyridine according to claim 3 of the formula ##STR238##

5. A compound according to claim 3, wherein such compound is methyl 7-[5-cyano-2-(4-fluorophenyl)-4-isopropyl-6-methyl-pyrid-3-yl]-3,5-dihydro xy-hept-6-enoate of the formula ##STR239##

6. A composition for inhibiting cholesterol biosynthesis and HMB-CoA reductase comprising an amount effective therefor a compound according to claim 3 association with a pharmaceutically acceptable diluent.

7. A method of treating a patient afflicted with hyperlipoproteinaemia, lipoproteinaemia or arteriosclerosis which comprises administering to said patient in need of such treatment, an effective amount of a compound according to claim 3.

8. A method of treating a patient afflicted with hyperlipoproteinaemia, lipoproteinaemia or arteriosclerosis which comprises administering to said patient in need of such treatment, an effective amount of a compound according to claim 5.

9. A compound according to claim 3, wherein such compound is methyl erythro-(E)-7-[2-(4-fluorophenyl)-4-isopropyl-5-methoxymethyl-6-methyl-pyr id-3-yl]-3,5-dihydroxy-hept-6-enoate of the formula ##STR240##
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