.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,169,382

« Back to Dashboard

Details for Patent: 5,169,382

Title: Membrane for electrotransport transdermal drug delivery
Abstract:A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rates in in vitro testing.
Inventor(s): Theeuwes; Felix (Los Altos, CA), Gyory; J. Richard (Los Altos, CA), Haak; Ronald P. (Cupertino, CA)
Assignee: Alza Corporation (Palo Alto, CA)
Filing Date:Jan 30, 1991
Application Number:07/648,269
Claims:1. An iontophoretic agent delivery electrode assembly adapted for placement on a body surface for iontophoretic delivery of an analgesic drug therethrough, the electrode assembly including a drug reservoir, a means for connecting said drug reservoir to a source of electrical power, and a membrane for controlling analgesic drug delivery from the electrode assembly, the membrane being positioned between said reservoir and said body surface, the membrane exhibiting an electrically-assisted flux (J.sub.EK) of the analgesic drug therethrough and impeding passive flux (J.sub.P) of the analgesic therethrough, the membrane exhibiting a ratio of J.sub.EK :J.sub.P of at least about 2.5,

the drug reservoir containing an analgesic drug to be delivered through the body surface, the drug being selected from the group consisting of fentanyl, sufentanil, analogues of fentanyl, analogues of sufentanil and pharmaceutically acceptable salts thereof.

2. The electrode assembly of claim 1, wherein the analgesic drug comprises a water soluble fentanyl salt.

3. The electrode assembly of claim 1, wherein the analgesic drug comprises a water soluble sufentanil salt.

4. The electrode assembly of claim 1, wherein said membrane is comprised of a hydrophilic resin blended into a hydrophobic polymeric matrix.

5. The electrode assembly of claim 4, wherein said hydrophilic resin is cross-linked polyvinylpyrrolidone.

6. The electrode assembly of claim 4, wherein said hydrophobic polymeric matrix is an ethylene vinyl acetate copolymer having a vinyl acetate content of about 1 to 40 wt. %.

7. The electrode assembly of claim 1, wherein the membrane exhibits a resistivity of less than about 10 kohm-cm.sup.2.

8. The electrode assembly of claim 1, wherein the source of electrical power provides a current density of about 50 to 625 .mu.A/cm.sup.2.

9. The electrode assembly of claim 1, wherein the source of electrical power provides a current density of about 100 .mu.A/cm.sup.2.

10. The electrode assembly of claim 1, wherein the drug comprises fentanyl or a pharmaceutically acceptable analogue or salt thereof.

11. The electrode assembly of claim 1, wherein the drug comprises sufentanil or a pharmaceutically acceptable analogue or salt thereof.

12. The electrode assembly of claim 1, including a current distributing electrode electrically connected between the drug reservoir and the source of electrical power.

13. The electrode assembly of claim 1, wherein the membrane is comprised of a material selected from the group consisting of polycarbonates, polyesters, polyamides, styrene-acrylic acid copolymers, polyurethanes, cellulose esters and polyalkylenes.

14. An electrically powered iontophoretic delivery device including a donor electrode assembly which contains a drug reservoir, the donor electrode assembly being adapted to be placed in drug transmitting relation with a body surface, a counter electrode assembly adapted to be placed in agent transmitting relation with a body surface and a source of electrical power adapted to be electrically connected to the donor electrode assembly and the counter electrode assembly, wherein the donor electrode assembly contains: (1) a membrane for controlling analgesic drug delivery from the electrode assembly, the membrane being positioned between said drug reservoir and said body surface, the membrane exhibiting an electrically-assisted flux (J.sub.EK) of the analgesic drug therethrough and impeding passive flux (J.sub.P) of the analgesic drug therethrough, the membrane exhibiting a ratio of J.sub.EK :J.sub.P of at least about 2.5, and (2) an ionized or ionizable source of an analgesic drug selected from the group consisting of fentanyl, sufentanil, analogues of fentanyl, analogues of sufentanil and pharmaceutically acceptable salts thereof.

15. The device of claim 14, wherein the drug comprises fentanyl or a pharmaceutically acceptable analogue or salt thereof.

16. The device of claim 14, wherein the drug comprises sufentanil or a pharmaceutically acceptable analogue or salt thereof.

17. The device of claim 14, wherein the membrane exhibits a resistivity of less than about 10 kohm-cm.sup.2.

18. The device of claim 14, wherein said membrane is comprised of a hydrophilic resin blended into a hydrophobic polymeric matrix.

19. The device of claim 14 wherein the source of electrical power provides a current density of about 50 to 625 .mu.A/cm.sup.2.

20. The device of claim 14, wherein the source of electrical power provides a current density of about 100 .mu.A/cm.sup.2.

21. The device of claim 14, wherein the donor electrode assembly includes a current distributing electrode electrically connected between the drug reservoir and the source of electrical power.

22. The device of claim 14, wherein the membrane is comprised of a material selected from the group consisting of polycarbonates, polyesters, polyamides, styrene-acrylic acid copolymers, polyurethanes, cellulose esters and polyalkylenes.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc