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Details for Patent: 5,164,369

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Details for Patent: 5,164,369

Title: Pulmonary surfactant protein and related polypeptide
Abstract:The present invention relates to a human SP18 monomer protein-related polypeptide useful in forming a synthetic pulmonary surfactant. The present invention also relates to a method of treating neonatal respiratory distress syndrome comprising adminstering a therapeutically effective amount of synthetic pulmonary of the present invention. Further contemplated by the present invention is a composition containing human SP18 monomer and human SP18 dimer but no other pulmonary surfactant proteins. A recombinant DNA molecule capable of expressing, without post-translational proteolytic processing, mature human SP18 monomer, and methods of using the recombinant DNA molecule are also contemplated.
Inventor(s): Cochrane; Charles G. (La Jolla, CA), Revak; Susan D. (San Diego, CA)
Assignee: The Scripps Research Institute (La Jolla, CA)
Filing Date:Jan 04, 1989
Application Number:07/293,201
Claims:1. A polypeptide having an amino acid residue sequence selected from the group consisting of:

DLLLLDLLLLDLLLLDLLLLD,

RLLLLRLLLLRLLLLRLLLLR,

RLLLLLLLLRLLLLLLLLRLL,

RRLLLLLLLRRLLLLLLLRRL,

RLLLLCLLLRLLLLLCLLLR,

RLLLLLCLLLRLLLLCLLLRLL, and

RLLLLCLLLRLLLLCLLLRLLLLCLLLR.

2. A synthetic pulmonary surfactant comprising a pharmaceutically acceptable phospholipid admixed with a polypeptide having an amino acid residue sequence selected from the group consisting of:

DLLLLDLLLLDLLLLDLLLLD,

RLLLLRLLLLRLLLLRLLLLR,

RLLLLLLLLRLLLLLLLLRLL,

RRLLLLLLLRRLLLLLLLRRL,

RLLLLCLLLRLLLLLCLLLR,

RLLLLLCLLLRLLLLCLLLRLL, and

RLLLLCLLLRLLLLCLLLRLLLLCLLLR,

said polypeptide, when admixed with a pharmaceutically acceptable phospholipid, forming a synthetic pulmonary surfactant having a surfactant activity greater than the surfactant activity of the phospholipid alone.

3. A method of treating respiratory distress syndrome comprising administering a therapeutically effective amount of a synthetic pulmonary surfactant, said surfactant comprising a pharmaceutically acceptable phospholipid admixed with an effective amount of a polypeptide having an amino acid residue sequence selected from the group consisting of:

DLLLLDLLLLDLLLLDLLLLD,

RLLLLRLLLLRLLLLRLLLLR,

RLLLLLLLLRLLLLLLLLRLL,

RRLLLLLLLRRLLLLLLLRRL,

RLLLLCLLLRLLLLLCLLLR,

RLLLLLCLLLRLLLLCLLLRLL, and

RLLLLCLLLRLLLLCLLLRLLLLCLLLR,

said polypeptide, when admixed with a pharmaceutically acceptable phospholipid, forming a synthetic pulmonary surfactant having a surfactant activity greater than the surfactant activity of the phospholipid alone.

4. A polypeptide having an amino acid residue sequence represented by the formula: RLLLLRLLLLRLLLLRLLLLR, said polypeptide, when admixed with a pharmaceutically acceptable phospholipid, forming a synthetic pulmonary surfactant having a surfactant activity greater than the surfactant activity of the phospholipid alone.

5. A synthetic pulmonary surfactant comprising a pharmaceutically acceptable phospholipid admixed with polypeptide wherein said polypeptide has an amino acid residue sequence represented by the formula: RLLLLRLLLLRLLLLRLLLLR, said polypeptide, when admixed with a pharmaceutically acceptable phospholipid, forming a synthetic pulmonary surfactant having a surfactant activity greater than the surfactant activity of the phospholipid alone.

6. A method of treating respiratory distress syndrome comprising administering a therapeutically effective amount of a synthetic pulmonary surfactant, said surfactant comprising a pharmaceutically acceptable phospholipid admixed with an effective amount of polypeptide wherein said polypeptide has an amino acid residue sequence represented by the formula: RLLLLRLLLLRLLLLRLLLLR, said polypeptide, when admixed with a pharmaceutically acceptable phospholipid, forming a synthetic pulmonary surfactant having a surfactant activity greater than the surfactant activity of the phospholipid alone.
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