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Details for Patent: 5,156,957

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Details for Patent: 5,156,957

Title: Follicle stimulating hormone
Abstract:Biologically active heterodimeric human FSH composed of an alpha subunit and a beta subunit, each subunit being synthesized by a cell having an expression vector containing heterologous DNA encoding the subunit.
Inventor(s): Reddy; Vemuri B. (Framingham, MA), Hsiung; Nancy (Wellesley, MA), Beck; Anton K. (Chesnut Hill, MA), Berstine; Edward G. (Boston, MA)
Assignee: Genzyme Corporation (Boston, MA)
Filing Date:Apr 24, 1989
Application Number:07/323,665
Claims:1. A mammalian cell comprising a transformed cell transformed by at least a first expression vector, said transformed cell being capable of producing a biologically active heterodimeric human fertility hormone comprised of an alpha subunit and a beta subunit, each said subunit being encoded in nature by a distinct mRNA, said hormone being human FSH, the alpha subunit of said hormone being encoded by said first expression vector and the beta subunit of said hormone being encoded by said first expression vector or by a second expression vector by which said transformed cell is also transformed, or progeny of said transformed cell containing the genetic information imparted by said vector or vectors.

2. A mammalian cell in accordance with claim 1, said first vector being a plasmid.

3. A mammalian cell in accordance with claim 1, the alpha and beta subunits of said heterodimeric hormone being encoded by said first expression vector.

4. A mammalian cell in accordance with claim 1, transcription of the alpha and beta subunits of said heterodimeric hormone being under the control of the mouse metallothionein promoter.

5. A mammalian cell in accordance with claim 1, said cell being a mouse cell.

6. A mammalian cell in accordance with claim 1, said first expression vector being autonomously replicating.

7. A mammalian cell in accordance with claim 1, wherein said beta subunit is encoded by a second expression vector, distinct from said first expression vector, said transformed cell also being transformed by said second expression vector.

8. A mammalian cell in accordance with claim 7, said second expression vector being autonomously replicating.

9. A method for producing the biologically active human fertility hormone FSH comprising culturing host mammalian cells in accordance with claim 1.

10. The method of claim 9, wherein said beta subunit is encoded by a second expression vector, distinct from said first expression vector, said transformed cell also being transformed by said second expression vector, and wherein each said expression vector is autonomously replicating.
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