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Serving hundreds of leading biopharmaceutical companies globally:

Boehringer Ingelheim
US Department of Justice
US Army
Argus Health

Generated: May 27, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,156,850

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Title: Dosage form for time-varying patterns of drug delivery
Abstract:A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
Inventor(s): Wong; Patrick S. (Palo Alto, CA), Theeuwes; Felix (Los Altos, CA), Ayer; Atul D. (Palo Alto, CA), Kuczynski; Anthony L. (Palo Alto, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Filing Date:Aug 31, 1990
Application Number:07/576,042
Claims:1. A method for administering a dose of a drug twice a day from a single dosage form to the gastrointestinal tract of a warm-blooded animal, which method comprises:

(a) admitting the dosage form into the gastrointestinal tract of the warm-blooded animal, said dosage form comprising:

(1) a compartment comprising a drug selected from the group consisting of verapamil, nimodipine, nitredipine, nisoldipine, nicardipine, felodipine, diltiazen, lidoflazine, tiapamil, guanabenz, isradipine, gallopamil, amlodipine, mioflazine, caroverene, diltiazem hydrochloride, and midazolam;

(2) a wall that surrounds and forms the compartment, said wall comprising a composition that is permeable to the passage of fluid;

(3) a first composition in the compartment comprising a viscosity of 100 centipoises to 10,000,000 centipoises and a polymer comprising a 9,000 to 10,000,000 molecular weight, said first composition drug-free for producing a drug-free interval prior to the administration of drug from the compartment;

(4) a second composition in the compartment comprising a drug selected from (1), in a dose amount of the drug for producing a therapeutic effect;

(5) a third composition in the compartment that expands in the presence of fluid that enters the device;

(6) exit means in the wall for connecting the exterior of the dosage form with the compartment; and

(7) a substantially immediate release dose amount of a drug selected from (1), on the exterior surface of the wall;

(b) administering a dose of drug from the exterior wall by contacting the drug with gastrointestinal fluid;

(c) imbibing fluid into the compartment thereby causing the third composition to expand and push against the second composition; and

(d) administering the dose of drug from the drug composition after the first drug-free composition is released from the compartment.

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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
Federal Trade Commission
Cantor Fitzgerald
Argus Health

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