Flexible Flat-Rate Plans

Flat-rate pricing for predictable budgeting

Short-term plans for project- or client-based billing

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,156,850

« Back to Dashboard

Details for Patent: 5,156,850

Title: Dosage form for time-varying patterns of drug delivery
Abstract:A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
Inventor(s): Wong; Patrick S. (Palo Alto, CA), Theeuwes; Felix (Los Altos, CA), Ayer; Atul D. (Palo Alto, CA), Kuczynski; Anthony L. (Palo Alto, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Filing Date:Aug 31, 1990
Application Number:07/576,042
Claims:1. A method for administering a dose of a drug twice a day from a single dosage form to the gastrointestinal tract of a warm-blooded animal, which method comprises:

(a) admitting the dosage form into the gastrointestinal tract of the warm-blooded animal, said dosage form comprising:

(1) a compartment comprising a drug selected from the group consisting of verapamil, nimodipine, nitredipine, nisoldipine, nicardipine, felodipine, diltiazen, lidoflazine, tiapamil, guanabenz, isradipine, gallopamil, amlodipine, mioflazine, caroverene, diltiazem hydrochloride, and midazolam;

(2) a wall that surrounds and forms the compartment, said wall comprising a composition that is permeable to the passage of fluid;

(3) a first composition in the compartment comprising a viscosity of 100 centipoises to 10,000,000 centipoises and a polymer comprising a 9,000 to 10,000,000 molecular weight, said first composition drug-free for producing a drug-free interval prior to the administration of drug from the compartment;

(4) a second composition in the compartment comprising a drug selected from (1), in a dose amount of the drug for producing a therapeutic effect;

(5) a third composition in the compartment that expands in the presence of fluid that enters the device;

(6) exit means in the wall for connecting the exterior of the dosage form with the compartment; and

(7) a substantially immediate release dose amount of a drug selected from (1), on the exterior surface of the wall;

(b) administering a dose of drug from the exterior wall by contacting the drug with gastrointestinal fluid;

(c) imbibing fluid into the compartment thereby causing the third composition to expand and push against the second composition; and

(d) administering the dose of drug from the drug composition after the first drug-free composition is released from the compartment.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.