.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 5,149,319

« Back to Dashboard

Details for Patent: 5,149,319

Title: Methods for providing localized therapeutic heat to biological tissues and fluids
Abstract:Gas, gaseous precursors and prefluorocarbons are presented as novel potentiators for ultrasonic hyperthermia. The gas, gaseous precursors and perfluorocarbons which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.
Inventor(s): Unger; Evan C. (Tucson, AZ)
Assignee:
Filing Date:Sep 11, 1990
Application Number:07/581,027
Claims:1. A method for heat treating biological tissues and fluids which comprises:

(i) administering to the tissue or fluid to be treated a therapeutically effective amount of a hyperthermia potentiator selected from the group consisting of gas, gaseous precursors and perfluorocarbons; and

(ii) applying ultrasound to heat said tissue or fluid to a temperature of at least about 43.degree. C.

2. A method of claim 1 wherein said hyperthermia potentiator is selected from the group consisting of gas, gaseous precursors and perfluorocarbons.

3. A method of claim 2 wherein said hyperthermia potentiator is gas.

4. A method of claim 3 wherein said gas is selected from the group consisting of air, carbon dioxide, oxygen, nitrogen, xenon, argon, neon and helium.

5. A method of claim 3 wherein said gas consists of stabilized gas bubbles.

6. A method of claim 5 wherein said stabilized gas bubbles consist of stabilized air bubbles.

7. A method of claim 2 wherein said hyperthermia potentiator is a gaseous precursor.

8. A method of claim 7 wherein said gaseous precursor is selected from the group consisting of aminomalonate, sodium bicarbonate, methylactate and diazonium compounds.

9. A method of claim 2 wherein said hyperthermia potentiator is a perfluorocarbon.

10. A method of claim 9 wherein said perfluorocarbon is selected from the group consisting of perfluorooctyl iodide, perfluorotributylamine, trifluoropropylamine or perfluorooctlybromide.

11. A method of claim 1 wherein said hyperthermia potentiator is encapsulated in a liposome.

12. A method of claim 3 wherein said hyperthermia potentiator is encapsulated in a liposome.

13. A method of claim 7 wherein said hyperthermia potentiator is encapsulated in a liposome.

14. A method of claim 9 wherein said hyperthermia potentiator is encapsulated in a liposome.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc