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Details for Patent: 5,122,604

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Details for Patent: 5,122,604

Title: .beta.-lactam compounds
Abstract:Novel .beta.-lactam compounds belonging to carbapenem or penem derivatives useful as antimicrobial agents or intermediates therefor and a process for producing these compounds are disclosed.
Inventor(s): Sunagawa; Makoto (Osaka, JP), Matsumura; Haruki (Osaka, JP), Inoue; Takaaki (Hyogo, JP), Fukasawa; Masatomo (Hyogo, JP), Kato; Masuhiro (Osaka, JP)
Assignee: Sumitomo Pharmaceuticals Co., Ltd. (Osaka, JP)
Filing Date:May 21, 1990
Application Number:07/525,817
Claims:1. A compound of the formula: ##STR386## wherein R1 represents 1-hydroxyethyl or a protected 1-hydroxyethyl; R2and R3 each independently represent a hydrogen atom or a protecting group; X represents an alkyl (C1-C3) substituted or unsubstituted methylene group; Y represents (1) an unsubstituted or alkyl (C1-C3) substituted guanidyl group, (2) an unsubstituted or substituted hydrazino group wherein the substituent is an alkyl (C1-C3) group, (3) a group represented by the formula (4-a): --NHOR8-a (4-a) wherein R8-a represents a hydrogen atom or an alkyl (C1-C3) group or (4) a group represented by the formula (2-a): ##STR387## wherein (A) R5 is (a) an alkyl (C1-C4) group which is substituted with a mono- or di-alkyl-(C1-C3)-substituted aminocarbonyl group or carboxyl group or (b) a pyridyl group and R6 is a hydrogen atom or an alkyl (C1-C4) group, or (B) R5 and R6 jointly represent an alkylene chain to form, together with the adjacent nitrogen atom, (a) a substituted 3- to 7-membered cyclic amino group wherein the substituent is an alkyl (C1-C3) group, carbamoyl group, a carboxyl group, a mono- or di-alkyl-(C1-C3) substituted aminocarbonyl group or a hydroxyl group, (b) an unsubstituted 3- to 7-membered cyclic amino group which may contain double bond(s) in the ring thereof, or (c) ##STR388##
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