|Title:||Difluro antivirals and intermediate therefor|
|Abstract:||A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.|
|Inventor(s):||Hertel; Larry W. (Indianapolis, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
|Filing Date:||Feb 07, 1991|
|Claims:||1. A difluoro-desoxy carbohydrate of the formula ##STR11## wherein X is hydroxy or a leaving group; and the Y groups independently are hydrogen or hydroxy-protecting groups. |
2. A carbohydrate of claim 1 which is in the ribose form.
3. A carbohydrate of claim 2 wherein X is hydroxy.
4. A carbohydrate of claim 1 wherein X is hydroxy.
5. A carbohydrate of claim 3 wherein Y is hydrogen.
6. A carbohydrate of claim 4 wherein Y is hydrogen.
7. A carbohydrate of claim 1 wherein X is a sulfonate leaving group.
8. A carbohydrate of claim 2 wherein X is a sulfonate leaving group.
9. A carbohydrate of claim 7 wherein Y is a silyl hydroxy-protecting group.
10. A carbohydrate of claim 8 wherein Y is a silyl hydroxy-protecting group.
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