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Details for Patent: 5,118,820

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Details for Patent: 5,118,820

Title: Difluro antivirals and intermediate therefor
Abstract:A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.
Inventor(s): Hertel; Larry W. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Filing Date:Feb 07, 1991
Application Number:07/652,349
Claims:1. A difluoro-desoxy carbohydrate of the formula ##STR11## wherein X is hydroxy or a leaving group; and the Y groups independently are hydrogen or hydroxy-protecting groups.

2. A carbohydrate of claim 1 which is in the ribose form.

3. A carbohydrate of claim 2 wherein X is hydroxy.

4. A carbohydrate of claim 1 wherein X is hydroxy.

5. A carbohydrate of claim 3 wherein Y is hydrogen.

6. A carbohydrate of claim 4 wherein Y is hydrogen.

7. A carbohydrate of claim 1 wherein X is a sulfonate leaving group.

8. A carbohydrate of claim 2 wherein X is a sulfonate leaving group.

9. A carbohydrate of claim 7 wherein Y is a silyl hydroxy-protecting group.

10. A carbohydrate of claim 8 wherein Y is a silyl hydroxy-protecting group.
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