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Details for Patent: 5,102,666

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Details for Patent: 5,102,666

Title: Calcium polycarbophil controlled release composition and method
Abstract:Controlled release compositions comprising calcium polycarbophil and an active agent selected from the group consisting of medicinal agents, breath fresheners, and flavors, and a method of controlled release of such an active agent.
Inventor(s): Acharya; Ramesh N. (Lake Forest, IL)
Assignee: Oramed, Inc. (Mundelein, IL)
Filing Date:Sep 11, 1990
Application Number:07/580,854
Claims:1. A polymeric controlled release composition comprising a reaction complex formed by the interaction of (1) a calcium polycarbophil component which is a water-swellable, but water-insoluble, fibrous, cross-linked carboxy-functional polymer, said polymer containing (1) a plurality of repeating units of which at least about 80 percent contain at least one carboxyl functionality, and (b) about 0.05 to about 1.5 percent cross-linking agent substantially free from polyalkenyl polyether, said percentages being based upon the weights of unpolymerized repeating unit and cross-linking agent, respectively, with (2) water, in the presence of an active agent selected from the group consisting of medicinal agents, breath fresheners, and flavors, wherein the amount of calcium polycarbophil present is from about 0.1 to about 99 percent, the amount of active agent present is from about 0.0001 to about 65 percent, by weight, based upon of the composition, and the amount of water present is from about 5 to about 200 percent, based upon the weight of calcium polycarbophil, said interaction being at a pH from about 3 to about 10, and the calcium polycarbophil being originally present, prior to said interaction, in the form of the calcium salt, having a calcium content from about 5 to about 25 percent, based on the weight of the polycarbophil.

2. The composition according to claim 1 wherein said active agent is a medicament.

3. The composition according to claim 2 wherein said polymeric composition also comprises a hydrophilic colloid.

4. The composition according to claim 3 wherein the said polymeric composition also comprises simple or complex carbohydrates or polyols.

5. The composition according to claim 3 wherein said polymeric composition also comprises one or more cosolvents selected from the group consisting of glycerol, propylene glycol and polyethylene glycol.

6. The composition according to claim 3 which is formed by combining a two component system comprising as one component a polymer phase containing calcium polycarbophil and as the second component a liquid phase containing water or optionally other solvents and the complex is formed at the time of use.

7. The composition according to claim 3 which is formed, in situ by combining a polymer phase dispersed in a nonpolar solvent with water from body fluid, when administered parenterally.

8. The composition according to claim 3 wherein at least about 90 percent of said polymer repeating units contain at least one carboxyl functionality.

9. The composition according to claim 3 wherein at least about 95 percent of said polymer repeating units contain at least one carboxyl functionality.

10. The method according to claim 9 wherein said composition comprises an intimate mixture of said reaction complex and said active agent.

11. The composition according to claim 3 wherein said polymer contains about 0.1 to about 1 percent by weight of polymerized cross-linking agent.

12. The composition according to claim 3 wherein said carboxyl functionality is provided by polymerized acrylic acid.

13. The composition according to claim 3 wherein the ratio by weight of said reaction complex to said active agent is from about 200,000:1 to about 1:100.

14. A method of controlled release treatment comprising the steps of:

(a) providing a polymeric complex and a therapeutically effective amount of an active agent contained within said complex, said polymeric complex comprising a reaction complex formed by the reaction of (1) a water-swellable, but water-insoluble, fibrous cross-linked carboxy-functional polymer, said polymer containing (a) a plurality of repeating units of which at least about 80 percent contain at least one carboxyl functionality and (b) about 0.05 to about 1.5 percent cross linking agent substantially free from polyalkenyl polyether, said percentages being based upon the weights of the unpolymerized repeating unit and cross-linking agent, respectively, or a salt thereof, with (2) water, said interaction being performed in the presence of an active agent, selected from the group consisting of medicinal agents, wherein the amount of calcium polycarbophil present is from about 0.1 to about 99 percent, the amount of active agent present is from about 0.0001 to about 65 percent, by weight, based upon the weight of the composition, and the amount of water present is from about 5 to about 200 percent, based upon the weight of calcium polycarbophil, said interaction being at a pH from about 3 to about 10, and the calcium polycarbophil being originally present, prior to said interaction, in the form of the calcium salt, having a calcium content from about 5 to about 25 percent, based on the weight of the polycarbophil; and

(b) contacting an area of skin or mucous membrane to be treated with said composition for a period of time that is sufficient to allow a therapeutically effective amount of said active agent to be released from the complex.
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