|Title:|| Treatment of human viral infections|
|Abstract:||Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose. Additionally, there is disclosed the treatment of Kaposi's sarcoma with 3'-azido-3'-deoxythymidine (AZT) and the synergistic activity in the treatment of humans infected with HTLV-III of AZT and interferon as well as AZT and acyclovir.|
|Inventor(s):|| Rideout; Janet L. (Raleigh, NC), Barry; David W. (Chapel Hill, NC), Lehrman; Sandra N. (Durham, NC), St. Clair; Martha H. (Durham, NC), Furman; Phillip A. (Durham, NC) |
|Assignee:|| Burroughs Wellcome Co. (Research Triangle Park, NC) |
|Filing Date:||Apr 18, 1990|
|Claims:||1. A method of treating a human being diagnosed as having Kaposi's sarcoma comprising administering to said human being a non-toxic, effective amount of 3'-azido-3'-deoxythymidine or its 5'-mono-, 5'-di-, or 5'-triphosphate, or a pharmaceutically acceptable salt thereof. |
2. The method of claim 1 wherein 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable salt thereof is administered.
3. The method of claim 1 wherein the 5'-monophosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable salt thereof is administered.