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Details for Patent: 5,070,107

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Details for Patent: 5,070,107

Title: Systemic antiviral treatment
Abstract:Systemic antiviral treatment using a narrow class of aliphatic straight-chain saturated monohydric alcohols which have from 27 to 32 carbons in the chain in physiologically compatible compositions for injection or trans-mucus membrance introduction into humans and other mammals is disclosed.
Inventor(s): Katz; David H. (La Jolla, CA)
Assignee: Lidak Pharmaceuticals (La Jolla, CA)
Filing Date:Nov 02, 1989
Application Number:07/430,822
Claims:1. A method of treating humans or other mammals for viral infections, comprising intravenous introduction into the human or other mammal suspected of having a viral infection with an effective amount of from about 0.1 mg to about 2 gm per 50 kg of body weight of a composition consisting of one or more C-27 to C-32 aliphatic alcohols in a physiologically compatible carrier.

2. A method of treating humans or other mammals for viral infections, comprising intramuscular introduction into the human or other mammal suspected of having a viral infection with an effective amount of from about 0.1 mg to about 2 gm per 50 kg of body weight of a composition consisting of one or more C-27 to C-32 aliphatic alcohols in a physiologically compatible carrier.

3. A method of treating humans or other mammals for viral infections, comprising trans-mucus membranal introduction into the human or other mammal suspected of having a viral infection with an effective amount of from about 0.1 mg to about 2 gm per 50 kg of body weight of a composition consisting of one or more C-27 to C-32 aliphatic alcohols in a physiologically compatible carrier.

4. A method of treating humans or other mammals for viral infections, comprising transdermal penetration into the human or other mammal suspected of having a viral infection with an effective amount of from about 0.1 mg to about 2 gm per 50 kg of body weight of a composition consisting of one or more C-27 to C-32 aliphatic alcohols in a physiologically compatible carrier.

5. A method of preventing or inhibiting the infection of humans or other mammals for viral infections, comprising intravenous introduction into the human or other mammal suspected of having a viral infection with an effective amount of from about 0.1 mg to about 2 gm per 50 kg of body weight of a composition consisting of one or more C-27 to C-32 aliphatic alcohols in a physiologically compatible carrier.

6. A method of preventing or inhibiting the infection of humans or other mammals for viral infections, comprising intramuscular introduction into the human or other mammal suspected of having a viral infection with an effective amount of from about 0.1 mg to about 2 gm per 50 kg of body weight of a composition consisting of one or more C-27 to C-32 aliphatic alcohols in a physiologically compatible carrier.

7. A method of preventing or inhibiting the infection of humans or other mammals, comprising trans-mucus membranal introduction into the human or other mammal suspected of having a viral infection with an effective amount of from about 0.1 mg to about 2 gm per 50 kg of body weight of a composition consisting of one or more C-27 to C-32 aliphatic alcohols in a physiologically compatible carrier.

8. A method of preventing or inhibiting the infection of humans or other mammals, comprising transdermal penetration into the human or other mammal suspected of having a viral infection with an effective amount of from about 0.1 mg to about 2 gm per 50 kg of body weight of a composition consisting of one or more C-27 to C-32 aliphatic alcohols in a physiologically compatible carrier.

9. A physiologically compatible solution which can be injected into humans or other mammals for viral infections intravenously or intramuscularly consisting essentially of a composition consisting of one or more C-27 to C-32 aliphatic alcohols in a physiologically compatible, intravenously or intramuscularly injectable carrier.

10. A physiologically compatible transdermal medication for introduction through the mucous membranes into humans or other mammals for viral infections consisting essentially of a composition consisting of one or more C-27 to C-32 aliphatic alcohols and a penetration-enhancing compound.

11. A method of preventing conception and reducing the risk of viral infection comprising introducing a composition consisting essentially of one or more aliphatic alcohols having from 27 to 32 carbons in a suitable carrier into the vagina substantially contemporaneously with or before intercourse.

12. An anti-viral suppository for trans-membranal introduction into the vagina or anus of a human or other mammal of a composition consisting essentially of one or more aliphatic alcohols having from 27 to 32 carbons in a physiologically acceptable carrier which is a solid at ambient room temperature and which melts at approximately 37.degree. C.

13. A method of treating humans and mammals for viral infections comprising introducing a composition consisting essentially of one or more aliphatic alcohols having from 27 to 32 carbons through a membrane into the circulatory system of a human or mammal suspected of having a viral infection with an effective amount of from about 0.1 mg to about 2 gm per 50 kg of body weight comprising inserting such alcohol composition in a physiologically acceptable liquid, cream, gel or suppository carrier into the anus or vagina of the human or mammal to be treated.
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