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Generated: December 18, 2017

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Title: Process for the manufacture of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate
Abstract:A process for the preparation of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate, a non-hygroscopic material which can be used as a pharmaceutical in the treatment of depression.
Inventor(s): Jeffery; James E. (Nottingham, GB2), Whybrow; Derek (Nottingham, GB2)
Assignee: Boots Company, PLC (Nottingham, GB2)
Filing Date:Jan 19, 1990
Application Number:07/467,471
Claims:1. A process for the preparation of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate comprising recrystallising N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride from a medium consisting of or containing water.

2. A process as claimed in claim 1 in which the medium containing water is a mixture of water and a water-immiscible solvent.

3. A process as claimed in claim 2 in which the water-immiscible solvent is toluene, xylene or cyclohexane.

4. A process as claimed in claim 1 in which the solvent containing water is a mixture of water and a water-miscible solvent.

5. A process as claimed in claim 4 in which the water-miscible solvent is acetone, propan-2-ol , industrial methylated spirit, 2-ethoxyethanol, 1,2-dimethoxyethane, tetrahydrofuran, 1,4-dioxan or methyl acetate.
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Serving leading biopharmaceutical companies globally:

Moodys
QuintilesIMS
Farmers Insurance
Queensland Health
Covington
Chinese Patent Office
Fish and Richardson
Teva
Express Scripts
Merck

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