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|Title:||Process for the manufacture of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate|
|Abstract:||A process for the preparation of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate, a non-hygroscopic material which can be used as a pharmaceutical in the treatment of depression.|
|Inventor(s):||Jeffery; James E. (Nottingham, GB2), Whybrow; Derek (Nottingham, GB2)|
|Assignee:||Boots Company, PLC (Nottingham, GB2)|
|Filing Date:||Jan 19, 1990|
|Claims:||1. A process for the preparation of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate comprising recrystallising N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride from a medium consisting of or containing water. |
2. A process as claimed in claim 1 in which the medium containing water is a mixture of water and a water-immiscible solvent.
3. A process as claimed in claim 2 in which the water-immiscible solvent is toluene, xylene or cyclohexane.
4. A process as claimed in claim 1 in which the solvent containing water is a mixture of water and a water-miscible solvent.
5. A process as claimed in claim 4 in which the water-miscible solvent is acetone, propan-2-ol , industrial methylated spirit, 2-ethoxyethanol, 1,2-dimethoxyethane, tetrahydrofuran, 1,4-dioxan or methyl acetate.
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