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Details for Patent: 5,053,419

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Details for Patent: 5,053,419

Title: Treatment of AIDS dementia, myelopathy and blindness
Abstract:A method of reducing death of CNS neurons in a human patient infected with a human immunodeficiency virus, involving administering to the patient a compound capable of reducing the gp120-responsive rise in free Ca.sup.++ ion concentration in the CNS neurons of the patient, in a concentration effective to cause such reduction.
Inventor(s): Lipton; Stuart A. (Newton, MA)
Assignee: The Children's Medical Center Corporation (Boston, MA)
Filing Date:Mar 30, 1990
Application Number:07/502,296
Claims:1. A method of reducing death of CNS neurons in a human patient infected with a human immunodeficiency virus, comprising administering to said patient a compound capable of reducing the gp120 responsive rise in free Ca.sup.++ ion concentration in said CNS neurons of said patient, in a concentration effective to cause such reduction.

2. The method of claim 1 wherein the blood of said human patient contains antibodies to HIV 1.

3. The method of claim 1 wherein said human patient manifests symptoms of the AIDS related complex or acquired immune deficiency syndrome.

4. The method of claim 1, said compound being capable of crossing the blood brain barrier.

5. The method of claim 1, said compound being nimodipine or Smith Kline drug no. 9512.

6. The method of claim 1, said nimodipine being administered to said patient orally or intravenously.

7. The method of claim 1, said compound being administered to said patient intrathecally or intravitreally.

8. The method of claim 1, said compound being one or more of nifedipine, verapamil, nitrendipine, or diltiazem.

9. The method of claim 5, in which said compound is nimodipine.

10. The method of claim 1, said compound being nicardipine, flunarizine, or diproteverine.
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