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Details for Patent: 5,035,877

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Details for Patent: 5,035,877

Title: Non-ionic contrast media from ionic contrast media
Abstract:Novel non-ionic contrast media are efficiently prepared from generally available ionic contrast media. Particularly, polyhydroxyhalohydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.
Inventor(s): Sovak; Milos (Rancho Santa Fe, CA), Ranganathan; Ramachandran (San Diego, CA)
Assignee: Cook Imaging Corporation (Bloomington, IN)
Filing Date:Sep 14, 1990
Application Number:07/582,791
Claims:1. In a method of X-raying a host employing a contrast medium, the improvement which comprises employing as a contrast medium 5-(N-2,3-dihydroxypropylacetamido)-2,4,6-triiodo-N-(2,3-dihydroxypropyl)-N '-(2-hydroxyethyl)-isophthalamide.
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