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Details for Patent: 5,032,386

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Details for Patent: 5,032,386

Title: Antiplaque antibacterial oral composition
Abstract:An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, about 0.25-0.35% by weight of a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxy diphenyl ether (triclosan) and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
Inventor(s): Gaffar; Abdul (Princeton, NJ), Nabi; Nuran (No. Brunswick, NJ), Afflitto; John (Brookside, NJ), Stringer; Orum (Yardley, PA)
Assignee: Colgate-Palmolive Company (Piscataway, NJ)
Filing Date:Aug 25, 1989
Application Number:07/398,566
Claims:1. A process for delivering an effective plaque controlling amount of an antibacterial agent to oral tooth and gum surfaces and enhancing its retention thereon which comprises introducing into contact with tooth and gum surfaces in the oral cavity an oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, about 0.25%-0.35% by weight of a substantially water insoluble noncationic antibacterial agent, selected from the group consisting of halogenated diphenyl ethers, halogenated salicylanilides, benxoic esters, halogenated carbanilides and phenolic compounds, said oral composition dentifrice comprising at least one of a surface active-agent and a flavoring oil, and an effective amount of about 0.05-4% by weight of an antibacterial-enhancing agent which enhances delivery and adherence of said antibacterial agent to, and the retention thereof on, oral tooth and gum surfaces, wherein said antibacterial-enhancing agent is (a) a copolymer of maleic acid or anhydride with another inert ethylenically unsaturated polymerizable monomer or (b) poly (beta-styrene-phosphonic acid) or poly (alpha-styrenephosphonic acid) polymer or a copolymer of either styrenephosphonic acid with another ethylenically unsaturated monomer; wherein said oral composition dentifrice is free of polyphosphate anticalculus agent in an effective anticalculus amount.

2. The process claimed in claim 1 wherein said surface active agent is present in amount of about 0.5-5% by weight.

3. The process claimed in claim 1 wherein said flavoring oil is present in amount of about 0.1-5% by weight.

4. The process claimed in claim 1 wherein said antibacterial-enhancing agent (a) is present and said other monomer of said copolymer is methyl vinyl ether in a 4:1 to 1:4 molar ratio with the maleic acid or anhydride.

5. The process claimed in claim 4 wherein said copolymer has a molecular weight of about 30,000-1,000,000 and is present in amount of about 0.1-2% by weight.

6. The process claimed in claim 5 wherein said copolymer has an average molecular weight of about 70,000.

7. A process for delivering an effective plaque controlling amount of triclosan antibacterial agent to oral tooth and gum surfaces and enhancing its retention thereon which comprises introducing into contact with tooth and gum surfaces in the oral cavity an oral composition dentifrice comprising in an orally acceptable vehicle, about 5-30% of a siliceous polishing agent, about 0.25%-0.35% of triclosan, at least one of a surface active agent and a flavoring oil, and about 0.05-4% of a copolymer of maleic acid or anhydride with methyl vinyl ether, wherein said oral composition dentifrice is free of polyphosphate anticalculus agent in an effective anticalculus amount.

8. A process for delivering an effective plaque controlling amount of triclosan antibacterial agent to oral tooth and gum surfaces and enhancing its retention thereon which comprises introducing into contact with tooth and gum surfaces in the oral cavity an oral composition dentifrice comprising in an orally acceptable vehicle, about 5-30% of a siliceous polishing agent, about 0.25%-0.35% of triclosan, at least one of a surface active agent and a flavoring oil, and about 0.05-4% of poly (alpha-styrenephosphonic acid), poly (beta-styrene phosphonic acid), or a copolymer of either styrene phosphonic acid monomer with the other or with another inert ethylenically unsaturated monomer.

9. The process according to any one of claims 1 to 8 containing an effective anticaries amount of a fluoride ion-providing source.
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