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Details for Patent: 5,015,463

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Details for Patent: 5,015,463

Title: Method to diagnose the presence or absence of tumor tissue
Abstract:A photosensitizing composition prepared by recovering a portion of hematoporphyrin derivative which has aggregate weight of more than 10 kd is useful in locating tumor tissue to which this improved photosensitizing drug homes. In the invention method, the subject is administered the improved drug and sufficient time is allowed to pass to permit accumulation of the drug in tumor tissue. The subject is then illuminated at suspected sites with radiation capable of absorption by the improved drug and which radiation produces fluorescence by the drug. Detection of the intensity of fluorescence indicates the quantity of drug at the measured location and permits assessment as to whether a tumor is present at that location.
Inventor(s): Dougherty; Thomas J. (Grand Island, NY), Potter; William R. (Grand Island, NY), Weishaupt; Kenneth R. (Sloan, NY)
Assignee: Health Research, Inc. (Buffalo, NY)
Filing Date:Apr 26, 1990
Application Number:07/515,179
Claims:1. A method to diagnose the presence or absence of tumor tissue at a location in a subject which method comprises

administering to said subject an effective amount of a composition consisting essentially of 10 kd aggregates of porphyrins which are fluorescent, photosensitizing and capable of localizing and being retained in tumor cells for a longer time than in normal tissues, and wherein the process for preparation of said composition comprises raising the pH of a hematoporphyrin derivative preparation in aqueous medium to 6.5-12 to obtain aggregates of 10 kd or greater and separating said aggregates from the remainder of the hematoporphyrin derivative preparation

in an amount effective to localize in a tumor at said suspected location;

waiting for sufficient time to permit the drug to clear normal tissue;

irradiating the suspected location with a wavelength absorbed by, and which elicits fluorescence from, said composition; and

measuring the fluorescence emitted.

2. The method of claim 1 wherein said waiting time is about 3 hours-2 days.
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