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|Title:||Bicyclic aminoacids as intermediates|
|Abstract:||Disclosed are cis, exo- and trans-compounds of the formula I ##STR1## in which n denotes 0,1 or 2, R.sub.1 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl which can optionally by substituted by amino, (C.sub.1 -C.sub.4)-acyl- or bezoylamino, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl, (C.sub.5 -C.sub.9)-cycloalkenyl, (C.sub.5 -C.sub.7)-cycloalkyl-(C.sub.1 -C.sub.4)-alkyl, aryl or partially hydrogenated aryl, which can, in each case, be substituted by (C.sub.1 -C.sub.2)-alkyl, (C.sub.2 -C.sub.2)-alkoxy or halogen, aryl-(C.sub.1 -C.sub.4)-alkyl, /which can be substituted as defined previously in the aryl radical/, a monocyclic or bicyclic sulfur or nitrogen and/or nitrogen heterocyclic radical, or a side chain of naturally occurring aminoacid, R.sub.2 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl or aryl-(C.sub.1 -C.sub.4)-alkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen, X denotes (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl or aryl which can be mono-, di- or tri- substituted by (C.sub.1 - C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, hydroxyl, halogen, nitro, amino, (C.sub.1 -C.sub.4)-alkylamino, di-(C.sub.1 -C.sub.4)-alkylamino or methylenedioxy, or indol-3-yl, or physiologically acceptable salts thereof, a process for the preparation thereof, agents containing them, their use as a medicine and intermediates for the preparation thereof.|
|Inventor(s):||Urbach; Hansjorg (Kronberg, DE), Henning; Rainer (Frankfurt am Main, DE), Teetz; Volker (Hofheim am Taunus, DE), Geiger; Rolf (Frankfurt am Main, DE), Becker; Reinhard (Wiesbaden, DE), Gaul; Holger (Niederneisen, DE)|
|Assignee:||Hoechst Aktiengesellschaft (Frankfurt, DE)|
|Filing Date:||Nov 21, 1984|
|Claims:||1. A compound of the formula ##STR34## wherein the H atoms on the C atoms in the 3a- and (6+n)a-positions are in the trans configuration relative to one another n is 0, 1 or 2; and W' is hydrogen or a group which can be cleaved by hydrogenolysis or acid hydrolysis. |
2. A compound as in claim 1 wherein W' is hydrogen, alkyl having 1 to 18 C atoms, or aralkyl having 7 to 10 C atoms.
3. A compound as in claim 1 wherein the hydrogen atoms on the bridgehead C atom in the 3a-position and on the C atom in the 2-position of the bicyclic ring system are on the same side of the reference plane of the ring atoms.
4. A compound as in claim 1 wherein the hydrogen atoms on the bridgehead C atom in the 3a-position and on the C atom in the 2-position of the bicyclic ring system are on the opposite side of the reference plane of the ring atoms.
5. 2.beta.,2a.alpha.,7a.beta.-Octahydroindole-2-carboxylic acid.