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Details for Patent: 4,994,276

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Details for Patent: 4,994,276

Title: Directly compressible sustained release excipient
Abstract:A free-flowing directly compressible granulation useful as a slow release pharmaceutical excipient is disclosed. The excipient includes a hydrodrophilic matrix which includes a heteropolysaccharide and a polysaccharide material capable of cross-linking the heteropolysaccharide, and an inert diluent.
Inventor(s): Baichwal; Anand R. (Poughkeepsie, NY), Staniforth; John N. (Bath, GB2)
Assignee: Edward Mendell Co., Inc. (Patterson, NY)
Filing Date:Sep 19, 1988
Application Number:07/246,368
Claims:1. A free-flowing, directly compressible slow release granulation for use as a pharmaceutical excipient, comprising

from about 20 to about 60 percent by weight of a hydrophilic material comprising a heteropolysaccharide and a polysaccharide gum capable of cross-linking said heteropolysaccharide in the presence of aqueous solutions, and

from about 40 to about 80 percent by weight of an inert pharmaceutical filler selected from the group consisting of a monosaccharide, a disaccharide, a polyhydric alcohol, and mixtures thereof, the ratio of said inert pharmaceutical filler to said hydrophilic material being from about 4:1 to about 0.67:1.

2. The granulation of claim 1, wherein said polysaccharide gum comprises a galactomannan.

3. The granulation of claim 1, wherein said heteropolysaccharide comprises from about 10 to about 90 percent by weight and said polysaccharide gum comprises from about 90 to about 10 percent by weight, of said hydrophilic material.

4. The granulation of claim 3, wherein the ratio of said heteropolysaccharide to said polysaccharide gum is about 1:1.

5. The granulation of claim 3, wherein said heteropolysaccharide comprises xanthan gum or derivatives thereof.

6. The granulation of claim 5, wherein said polysaccharide gum comprises a galactomannan.

7. The granulation of claim 6, wherein said galactomannan comprises locust bean gum.

8. The granulation according to claim 1 wherein a medicament is added and the resulting mixture provides a zero order controlled release when provided as a solid dosage form, the ratio of said medicament to said hydrophilic material being from about 1:3 to about 1:7.

9. The granulation of claim 7, wherein said inert pharmaceutical filler comprises lactose, dextrose, sucrose, fructose, microcrystalline cellulose, xylitol, sorbitol or mixtures thereof.

10. The granulation of claim 9 to which a medicament is added, the ratio of said medicament to said hydrophilic material being from about 1:3 to about 1:7.

11. The granulation of claim 9, wherein a medicament is added and the resultant mixture is compressed to form solid tablets, the ratio of said medicament to said hydrophilic material being from about 1:3 to about 1:7.

12. The granulation of claim 11, wherein at least 3.5 hours are required to release 50 percent of said medicament.

13. The granulation of claim 10, wherein the average particle size of said granules is from about 185 to about 250 microns.

14. The granulation according to claim 3, wherein said hydrophilic material further comprises a second polysaccharide gum.

15. The granulation according to claim 14, wherein said second polysaccharide gum is selected from the group consisting of tragacanth, accacia, karaya, alginates, agar, pectin, guar, hydroxypropyl guar, carrageenan, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methylcellulose, carboxymethyl cellulose, polyvinyl pyrollidone, and mixtures of any of the foregoing.

16. The granulation according to claim 14, wherein said second polysaccharide gum comprises propylene glycol alginate.

17. The granulation according to claim 14, wherein said second polysaccharide gum comprises a hydrocolloid, said hydrocolloid comprising up to about 50% by weight of said hydrophilic material.

18. The granulation according to claim 1, wherein a medicament is added and the resulting mixture is encapsulated, the ration of said medicament to said hydrophilic material being from about 1:3 to about 1:7.
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