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Details for Patent: 4,986,987

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Details for Patent: 4,986,987

Title: Pulsed drug delivery
Abstract:A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
Inventor(s): Ayer; Atul D. (Mountain View, CA), Theeuwes; Felix (Los Altos, CA), Wong; Patrick S. L. (Hayward, CA)
Assignee: Alza Corporation (Palo Alto, CA)
Filing Date:Feb 21, 1989
Application Number:07/312,845
Claims:1. A dosage form useful for the relief of motion sickness, said dosage form comprising:

(a) a wall comprising in at least a part a semipermeable composition permeable to the passage of an external fluid and substantially impermeable to the passage of drug formulation; which wall surrounds:

(1) a first layer comprising a timed delayed dosage amount of a dimenhydrinate formulation;

(2) a second layer comprising a hydrogel formulation that increases in volume in the presence of fluid;

(3) means for the timed delay of dimenhydrinate formulation from the interior of the dosage form interposed between the wall and the first layer;

(b) exit means in the wall for releasing the timed delayed dose of dimenhydrinate formulation from the dosage form; and,

(c) a dosage amount of a first immediate dose of dimenhydrinate on the exterior wall of the dosage form.

2. A dosage form for use as a cough relief for delivering an immediate dose and a timed delayed dose of dextromethorphan to a recipient, wherein the dosage form comprises:

(a) a wall comprising in at least a part a semipermeable composition permeable to the passage of an external fluid and substantially impermeable to the passage of drug formulation, which wall surrounds:

(1) a dosage amount of a dextromethorphan formulation;

(2) a hydrogel composition that increases in volume in the presence of fluid, said hydrogel composition in contact with the dextromethorphan formulation;

(3) means for delaying the release of the dextromethorphan formulation from the dosage form, said means interposed between the wall and the dextromethorphan formulation;

(b) at least one exit passageway in the wall for releasing the dextromethorphan formulation from the dosage form; and,

(c) a dosage amount of an immediate dose of a dextromethorphan carried by the exterior surface of the wall of the dosage form.

3. A dosage form for delivering a beneficial drug formulation to an environment of use, the dosage form comprising:

(a) a wall comprising at least in part a semipermeable composition permeable to the passage of an external fluid present in the environment of use and substantially impermeable to the passage of a beneficial drug formulation which wall surrounds and forms:

(b) a compartment;

(c) a drug formulation in the compartment that exhibits an osmotic pressure gradient across a semipermeable wall;

(d) lamina means positioned in the compartment between a passageway in the inside surface of wall which lamina surrounds the drug formulation for delaying the delivery of the drug formulation from the compartment;

(e) at least one exit means in the wall for communicating the exterior of the dosage form with the compartment for delivering the drug formulation from the dosage form; and,

(f) a releasable dosage amount of a beneficial drug formulation in contact with the exterior wall of the dosage form.
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