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Details for Patent: 4,985,557

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Details for Patent: 4,985,557

Title: Optically active pyridobenzoxazine derivatives and intermediates thereof
Abstract:An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.
Inventor(s): Hayakawa; Isao (Tokyo, JP), Atarashi; Shohgo (Tokyo, JP), Imamura; Masazumi (Tokyo, JP), Yokohama; Shuichi (Tokyo, JP), Higashihashi; Nobuyuki (Tokyo, JP), Sakano; Katsuichi (Tokyo, JP), Ohshima; Masayuki (Tokyo, JP)
Assignee: Daiichi Seiyaku Co., Ltd. (Tokyo, JP)
Filing Date:Mar 23, 1989
Application Number:07/327,653
Claims:1. An isolated 4-substituted benzoxazine derivative represented by the formula (X) ##STR9## wherein X.sub.1 and X.sub.2, which may be the same or different, each represents a halogen atom, R.sub.1 represents an alkyl group having 1 to 4 carbon atoms, and Q represents a group ##STR10## wherein R.sub.2 represents a substituted sulfonyl group, an alkoxycarbonyl group or an aralkyloxycarbonyl group, and n represents an integer of 1 to 3.
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