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Details for Patent: 4,983,400

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Details for Patent: 4,983,400

Title: Controlled release combination of carbidopa/levodopa
Abstract:A matrix or monolithic drug delivery system for the controlled release of carbidopa and levodopa consists of the two drugs uniformly dispersed in a polymer vehicle at a concentration that is greater than the solubility of either drug in the polymer. Treatment of parkinsonism with the controlled release formulation provides several advantages over treatment with the standard carbidopa/levodopa combination presently employed.
Inventor(s): Dempski; Robert E. (Dresher, PA), Scholtz; Edward C. (King of Prussia, PA), Nibbelink; Donald W. (Lansdale, PA), Reines; Scott A. (New Hope, PA)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Dec 01, 1989
Application Number:07/444,222
Claims:1. A controlled release solid oral dosage formulation consisting essentially of a uniform dispersion of 5-300 mg of carbidopa, 20-1200 mg of levodopa in a polymer vehicle of 2 to 120 mg of polymethyl methacrylate, whereby following administration the carbidopa and levodopa are released slowly and simultaneously from the formulation.

2. The controlled release solid oral dosage formulation of claim 1 consisting essentially of a uniform dispersion of 25-100 mg of carbipopa, 100-400 mg of levodopa, in a polymer vehicle of 2 to 120 mg of polymethyl methacrylate, whereby following administration the carbidopa and levodopa are released slowly and simultaneously from the formulation.

3. The formulation of claim 1 comprising 400 mg of levodopa, 100 mg of carbidopa and 120 mg of polymethyl methacrylate.
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