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Details for Patent: 4,983,392

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Details for Patent: 4,983,392

Title: Bioadhesive compositions and methods of treatment therewith
Abstract:A controlled release treatment composition and method of use are disclosed. The composition includes a bioadhesive and an effective amount of a treating agent. The bioadhesive is a water-swellable, but water-insoluble, fibrous, cross-linked carboxy-functional polymer containing (a) a plurality of repeating units of which at least about 80 percent contain at least one carboxyl functionality, and (b) about 0.05 to about 1.5 percent cross-linking agent substantially free from polyalkenyl polyether.
Inventor(s): Robinson; Joseph R. (Madison, WI)
Assignee: Bio-Mimetics, Inc. (Lexington, MA) Columbia Laboratories, Inc. (Miami, FL)
Filing Date:Dec 20, 1988
Application Number:07/287,464
Claims:1. A controlled release ophthalmic treatment composition including a bioadhesive and an effective amount of an ophthalmic treating agent, said bioadhesive comprising a water-swellable, but water-insoluble, particular cross-linked carboxyl-functional polymer having particles sized so that visual impairment is substantially minimized when said composition is contacted with a mucous membrane of the eye, said polymer containing (a) a plurality of repeating units of which at least about 80 percent contain at least the carboxyl functionally, and (b) about 0.05 to about 1.5 percent cross-linking agent substantially free from polyalkylenyl polyether, said percentages being based upon the weights of the unpolymerized repeating unit cross-linking agent, respectively.

2. A controller release ophthalmic treatment composition as recited in claim 1 wherein said bioadhesive and said treating agent are intimately admixed substantially uniformly.

3. A controlled release ophthalmic treatment composition as recited in claim 1 wherein at least about 90 percent of said polymer repeating units contain at least one carboxyl functionality.

4. A controlled release ophthalmic treatment composition as recited in claim 1 wherein at least about 95 percent of said polymer repeating units contain at least one carboxyl functionality.

5. A controlled release ophthalmic treatment composition as recited in claim 1 wherein said polymer contains about 0.1 to about 1 percent by weight of polymerized cross-linking agent.

6. A controlled release ophthalmic treatment composition as recited in claim 1 wherein said carboxyl functionality is provided by polymerized acrylic acid.

7. A controlled release ophthalmic treatment composition as recited in claim 1 wherein at least about 95 percent of said polymer repeating units contain at least one carboxyl functionality provided by acrylic acid, and said polymer contains about 0.1 to about 1 percent by weight of polymerized cross-linking agent.

8. A controlled release ophthalmic treatment composition as recited in claim 7 wherein said cross-linking agent is 3,4-dihydroxy-1,5-hexadiene.

9. A controlled release ophthalmic treatment composition as recited in claim 7 wherein said cross-linking agent is divinyl benzene.

10. A controlled release ophthalmic treatment composition as recited in claim 7 wherein said cross-linking agent is 2,5-dimethyl-1,5-hexadiene.

11. A controlled release ophthalmic treatment composition as recited in any one of claims 1-10, inclusive, wherein said ophthalmic treating agent constitutes an anti-inflammatory agent.

12. A controlled release opthahalmic treatment composition as recited in claim 11 wherein said anti-inflammatory agent is fluorometholone.
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