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Details for Patent: 4,956,388

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Details for Patent: 4,956,388

Title: 3-aryloxy-3-substituted propanamines
Abstract:The present invention provides 3-aryloxy-3-substituted propanamines capable of inhibiting the uptake of serotonin and norepinephrine.
Inventor(s): Robertson; David W. (Greenwood, IN), Wong; David T. (Indianapolis, IN), Krushinski, Jr.; Joseph H. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Filing Date:Jan 12, 1990
Application Number:07/462,925
Claims:1. A compound of the formula ##STR82## wherein: R.sup.1 is C.sub.5 -C.sub.7 cycloalkyl; ##STR83## each of R.sup.2 and R.sup.3 independently is hydrogen or methyl; each R.sup.4 independently is halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy or trifluoromethyl;

each R.sup.5 independently is halo, C.sub.1 -C.sub.4 alkyl or trifluoromethyl;

m is 0, 1 or 2;

n is 0 or 1; and

the pharmaceutically acceptable acid addition salts thereof.

2. A compound of claim 1 wherein Ar is ##STR84##

3. A compound of claim 1 wherein Ar is ##STR85##

4. A method for inhibiting norepinephrine uptake in mammals which comprises adminstering to a mammal requiring increased neurotransmission of norepinephrine a pharmaceutically effective amount of a compound of claim 1.

5. A method of treating depression in humans comprising adminstering to a human suffering from depression an effective antidepressant dose of a compound of claim 1.

6. A method of treating anxiety in human comprising adminstering to a human suffering from anxiety an effective antianxiety dose of a compound of claim 1.

7. A method of treating obesity in humans comprising adminstering to a human suffering from obesity an effective antiobesity dose of a compound of claim 1.

8. A method of suppressing the desire of humans to smoke comprising adminstering to a human in need of such suppression an effective dose to relieve the desire to smoke of a compound of claim 1.

9. A method of suppressing the desire of humans to consume alcohol comprising adminstering to a human in need of such suppression an effective dose to relieve the desire to consume alcohol of a compound of claim 1.

10. A pharmaceutical formulation comprising a compound of claim 1 and a pharmaceutically acceptable carrier, diluent or excipient therefor.
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