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Details for Patent: 4,953,572

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Details for Patent: 4,953,572

Title: Method and apparatus for aiding in the reduction of incidence of tobacco smoking
Abstract:A method and a composition for aiding in the reduction of the incidence of tobacco smoking which comprises a method of administering a nicotine containing aerosol spray to the oral cavity of an individual to provide a stimulation to the respiratory tract of the smoker, somewhat similar to that provided by normal tobacco smoke. The method also comprises a composition of a low concentration nicotine aerosol spray in which the spray droplets have a size and a range of between about one micron to about ten microns in diameter and which spray preferably contains nicotine in an amount of about 0.005 miligrams to about 0.03 miligrams per inhilation.
Inventor(s): Rose; Jed E. (Durham, NC), Jarvik; Murray E. (Santa Monica, CA), Rose; Karce D. (Healdsburg, CA)
Assignee:
Filing Date:Feb 19, 1988
Application Number:07/157,948
Claims:1. A low concentration nicotine aerosol spray for inhalation to aid in smoking incidence reduction, said aerosol spray having droplets within the size range of between about 1 micron to about 10 microns in diameter and with the droplet size selected to stimulate either the upper respiratory tract or the lower respiratory tract or both, and which spray contains nicotine which renders an amount of about 0.005 mg to about 0.03 mg per inhalation rendering a nicotine concentration substantially less than that obtained from a puff of cigarette smoke and which does not produce any significant level of nicotine still provides the throat and respiratory tract stimuli obtained from tobacco smoke and which also eliminates the harmful effects of nicotine in larger concentrations.

2. The aerosol spray of claim 1 further characterized in that the spray is contained in and dispensed from a nebulizer as a fine mist.

3. The aerosol spray of claim 1 further characterized in that the spray has droplets within a size range of about 1 to about 5 microns for stimulating lower respiratory regions.

4. The aerosol spray of claim 1 further characterized in that the spray has droplets within a size range of about 5 to about 10 microns for stimulating upper respiratory regions.

5. The aerosol spray of claim 1 further characterized in that the nicotine spray contains nicotine which renders from about 0.008 mg per inhalation to about 0.015 mg per inhalation.

6. A method of aiding in the reduction of incidence of tobacco smoking, said method comprising administering a nicotine containing aerosol spray to the oral cavity of an individual and which spray is comprised of droplets within a size range of between 1 micron to about 10 microns in diameter, said spray containing nicotine in an amount of about 0.005 mg to about 0.03 mg per inhalation rendering a nicotine concentration substantially less than that obtained from a puff of cigarette smoke and which does not produce any significant level of nicotine in the bloodstream of a user, but which low dose amount of nicotine still provides the throat and respiratory tract stimuli obtained from tobacco smoke and which also eliminates the harmful effects of nicotine in larger concentrations.

7. The method of claim 6 further characterized in that said method comprises varying the concentration of nicotine in a spray carrier to obtain a nicotine content proportionate to the nicotine concentration in the tobacco smoke to which the user is accustomed.

8. The method of claim 7 further characterized in that said method comprises varying the sizes of the droplets to correspond to the portion of the respiratory tract where stimulation is desired.

9. The method of claim 6 further characterized in that said method comprises administering the aerosol spray having droplets within a size range of about 1 micron to about 5 microns for stimulating the lower respiratory regions of a user.

10. The method of claim 6 further characterized in that said method comprises administering the aerosol spray having droplets within a size range of about 5 microns to about 10 microns for stimulating the upper respiratory regions of a user.

11. The method of claim 6 further characterized in that said method comprises administering an aerosol spray having a nicotine content which renders about 0.008 mg per inhalation to about 0.015 mg per inhalation.

12. A low concentration nicotine aerosol spray comprising a nicotine soluble liquid carrier, nicotine dissolved in and carried by said liquid carrier, said spray having droplets within the size range of between about 1 micron to about 10 microns in diameter and with the droplet size selected to stimulate either the upper respiratory tract or the lower respiratory tract or both, the nicotine being present in the carrier in an amount of about 0.5% to about 3% by weight to provide an aerosol spray containing about 0.005 mg to about 0.03 mg of nicotine per inhalation, rendering a nicotine concentration substantially less than that obtained from a puff of cigarette smoke and which does not produce any significant level of nicotine in the bloodstream of a user, but which low does amount of nicotine still provides the throat and respiratory tract stimuli obtained from tobacco smoke and which also eliminates the harmful effects of nicotine in larger concentrations.

13. The aerosol spray of claim 12 further characterized in that the spray is contained in and dispensed from a nebulizer as a fine mist.

14. The aerosol spray of claim 12 further characterized in that the spray has droplets within a size range of about 1 to about 5 microns for stimulating lower respiratory regions.

15. The aerosol spray of claim 12 further characterized in that the spray has droplets within a size range of about 5 to about 10 microns for stimulating upper respiratory regions.

16. The aerosol spray of claim 12 further characterized in that the nicotine spray contains nicotine which renders from about 0.008 mg per inhalation to about 0.015 mg per inhalation.

17. A method of aiding in the reduction of incidence of tobacco smoking, said method comprising administering a nicotine containing aerosol spray to the oral cavity of an individual and which spray is comprised of a nicotine soluble liquid carrier and nicotine dissolved in and carried by this liquid carrier to provide droplets within the size range of about 1 micron to about 10 microns in diameter, the size of the droplets being selected to stimulate either the upper respiratory tract or the lower respiratory tract or both of an individual, the nicotine being present in the carrier in an amount of about 0.5% to about 3% by weight to provide an aerosol spray containing 0.005 mg to about 0.03 mg of nicotine per inhalation, thereby rendering a nicotine concentration substantially less than that obtained from a puff of cigarette smoke and which does not produce any significant level of nicotine in the bloodstream of a user, but which low dose amount of nicotine still provides the throat and respiratory tract stimuli obtained from tobacco smoke and which also eliminates the harmful effects of nicotine in larger concentrations.

18. The method of claim 17 further characterized in that said method comprises varying the sizes of the droplets to correspond to the portion of the respiratory tract where stimulation is desired.

19. The method of claim 17 further characterized in that said method comprises administering the aerosol spray having droplets within a size range of about 1 to about 5 microns for stimulating the lower respiratory regions of a user.

20. The method of claim 17 further characterized in that said method comprises administering the aerosol spray having droplets within a size range of about 5 microns to about 10 microns for stimulating the upper respiratory regions of a user.

21. The method of claim 17 further characterized in that said method comprises administering an aerosol spray having a nicotine content which renders about 0.008 mg per inhalation to about 0.015 mg per inhalation.
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