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Serving 500+ biopharmaceutical companies globally:

Federal Trade Commission
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Cerilliant
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Farmers Insurance
Cipla
McKinsey
Colorcon
Medtronic
US Department of Justice

Generated: June 28, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,948,793

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Details for Patent: 4,948,793

Title: Treatment of autoimmune diseases with the morpholinoethyl ester of mycophenolic acid, and derivatives thereof
Abstract:The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, Y is hydrogen or morpholinoethyl, and where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, particularly for treatment of allograft rejection, especially including cardiac allograft rejection, pancreatic allograft rejection and renal allograft rejection, and for treating autoimmune diabetes. ##STR1##
Inventor(s): Allison; Anthony C. (Belmont, CA), Eugui; Elsie M. (Belmont, CA), Nelson; Peter H. (Los Altos, CA), Gu; Chee-Liang L. (Sunnyvale, CA), Lee; William A. (Palo Alto, CA)
Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA)
Filing Date:Jun 29, 1989
Application Number:07/373,413
Claims:1. A method of treating autoimmune diseases, which comprises administering to a mammal in need thereof a therapeutically effective amount of a compound represented by the formula: ##STR8## wherein: Y is morpholinoethyl; and

Z is hydrogen or --C(O)R,

where R is lower alkyl or aryl;

or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 comprising a method of treating autoimmune diabetes.

3. The method of claim 2 wherein Z is hydrogen.

4. The method of claim 1 wherein Z is hydrogen.
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Serving 500+ biopharmaceutical companies globally:

Merck
AstraZeneca
Dow
Boehringer Ingelheim
Novartis
Medtronic
Colorcon
Cerilliant
Deloitte
Queensland Health

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