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|Title:||Bioerodible articles useful as implants and prostheses having predictable degradation rates|
|Abstract:||A novel series of articles useful as implants and prostheses and methods for their preparation and use are provided which utilize polyanhydride polymeric matrices as a general class of materials. These articles are biocompatible, non-inflammatory and degrade predictably into non-toxic residues after introduction in-vivo. The articles may be formed in any desired dimensions and configuration and may take specific shape as vascular or skin grafts, as biodegradable sutures or as orthopedic appliances such as bone plates and the like.|
|Inventor(s):||D'Amore; Patricia (Brookline, MA), Leong; Kam W. (Cambridge, MA), Langer; Robert S. (Somerville, MA)|
|Assignee:||Massachusetts Institute of Technology (Cambridge, MA)|
|Filing Date:||Jun 15, 1987|
|Claims:||1. A method of forming an implantable article and implantation in vivo comprising the steps of: |
forming an implantable article from a biocompatible, bioerodible, hydrophobic, purified polyanhydride composition of the formula: ##STR8## wherein R is an organic group and n is at least 2, said polyanhydride being characterized by biocompatibility that results in minimal tissue irritation when implanted in vasculated tissue and degrading by hydrolysis at predictable and constant rates into non-toxic residues after introduction in vivo; and
locating said article in a subject at a preselected site, said article dimensions, configuration, and composition being selected to produce an implant having the required structure and physical properties to provide a desired function at the preselected site.
2. The method of claim 1 wherein said R group is selected from the group consisting of hydrocarbons of from 2 to 16 carbon atoms, ##STR9## wherein x is at least 2 and not greater than 16, ##STR10## wherein x is at least 1, ##STR11## wherein x is at least 1 and y is at least 1, ##STR12## wherein R' and R" are organic groups.
3. The method of claim 1 wherein said polyanhydride composition is implanted subcutaneously.
4. The method of claim 1 wherein said polyanhydride composition is implanted intramuscularly.
5. The method of claim 1 wherein said polyanhyride composition is implanted on tissue as a skin equivalent.
6. The method of claim 1 further comprising forming said polyanhydride composition into a bone prosthesis and locating said bone prosthesis at the appropriate site in the subject.
7. The method of claim 1 further comprising incorporating substances enhancing repair of body tissues and organs into said polyanhydride composition.
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