|Abstract:||Biologically active heterodimeric human FSH composed of an alpha subunit and a beta subunit, each subunit being synthesized by a cell having an expression vector containing heterologous DNA encoding the subunit.|
|Inventor(s):|| Reddy; Vemuri B. (Framingham, MA), Hsiung; Nancy (Wellesley, MA), Beck; Anton K. (Chestnut Hill, MA), Berstine; Edward G. (Boston, MA) |
|Assignee:|| Integrated Genetics, Inc. (Framingham, MA) |
|Filing Date:||Jan 30, 1985|
|Claims:||1. A method for producing biologically active, heterodimeric human FSH comprising culturing mammalian cells capable of glycosylating proteins, said cells comprising an expression vector encoding the alpha and beta subunits of said FSH. |
2. A vector comprising a DNA sequence encoding the beta subunit of human FSH.