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Generated: November 25, 2017

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Title: Producing anxiolytic activity and treating depression with 3(H)-indolones
Abstract:The present invention relates to the use of certain indolone derivatives in particular, 4-(2-di-n-propyl-aminoethyl)-2-(3H)-indolone in a method of treatment of Parkinsons disease.
Inventor(s): Owen; David A. A. (Welwyn Garden City, GB2)
Assignee: Smith Kline & French Laboratories Limited (Welwyn Garden City, GB2)
Filing Date:Mar 13, 1989
Application Number:07/322,386
Claims:1. A method of treatment of depression which comprises administering an effective non-toxic amount of a compound of structure (I) ##STR2## in which each R group is hydrogen or C.sub.1-4 alkyl;

R.sup.1 and R.sup.2 are each hydrogen or C.sub.1-4 alkyl;

R.sup.3 is hydrogen or hydroxy; and

n is 1 to 3;

or a pharmaceutically acceptable salt thereof to a subject in need thereof.

2. A method of treatment of depression which comprises administering an effective non-toxic amount of 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone to a subject in need thereof.

3. A method of treatment of depression which comprises administering an effective non-toxic amount of 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone hydrochloride to a subject in need thereof.

4. A method of producing anxiolytic activity which comprises administering an effective non-toxic amount of a compound of structure (I) ##STR3## in which each group R is hydrogen or C.sub.1-4 alkyl; R.sup.1 and R.sup.2 are each hydrogen or C.sub.1-4 alkyl;

R.sup.3 is hydrogen or hydroxy; and

n is 1 to 3;

or a pharmaceutically acceptable salt thereof to a subject in need thereof.

5. A method of producing anxiolytic activity which comprises administering an effective non-toxic amount of 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone to a subject in need thereof.

6. A method of producing anxiolytic activity which comprises administering an effective non-toxic amount of 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone hydrochloride to a subject in need thereof.
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Harvard Business School
Boehringer Ingelheim
McKinsey
Mallinckrodt
Novartis
Chubb
US Army
Express Scripts
Chinese Patent Office
US Department of Justice

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