.

Deeper Knowledge, Faster

  • Identify first generic entrants
  • Uncover prior art in expired and abandoned patents
  • Set up watchlists for daily email updates

► See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Daiichi Sankyo
Accenture
Citi
Cerilliant
Johnson and Johnson
Julphar
McKinsey
US Department of Justice
Queensland Health
Moodys

Generated: June 24, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,906,474

« Back to Dashboard

Details for Patent: 4,906,474

Title: Bioerodible polyanhydrides for controlled drug delivery
Abstract:A composition of matter suitable for implantation in the body to effect zero order drug release comprising a drug and a polymer of the formula: ##STR1## wherein R and R' can be the same or different and are hydrophobic organic linkages and n and m are integers of 1 or greater.
Inventor(s): Langer; Robert S. (Somerville, MA), Rosen; Howard (Montara, CA), Linhardt; Robert J. (Iowa City, IA), Leong; Kam (Cambridge, MA)
Assignee: Massachusetts Institute of Technology (Cambridge, MA)
Filing Date:May 21, 1984
Application Number:06/613,001
Claims:1. A composition of matter comprising a mixture of a therapeutic drug and a polymer of the formula: ##STR10## wherein R and R' can be the same or different and are hydrophobic organic linkages, the sum of n and m is between 10 and 106, and said polymer is polymerized from prepolymers formed from dicarboxylic acids, wherein the prepolymers are purified by recrystallization until the contaminants and degradation products present in the prepolymer are removed, said polymer being characterized by biocompatibility that results in minimal tissue irritation when implanted in vasculated tissue, and approximately zero order erosion and release rates of drug in vivo as a function of hydrolysis of the anhydride linkages in the polyanhydride.

2. The composition of claim 1 wherein R and R' are selected from the group consisting of an alkyl from 1 to 20 carbon atoms, p-carboxyphenoxymethane, benzyl, pyridine, and aromatic amino acids.

3. The composition of claim 2 wherein the amino acid is selected from the group consisting of phenylanine, tyrosine, tryptophan, and glycine.

4. The composition of claim 1 wherein the drug is selected from the group consisting of biologically active proteins, steroids, and antibiotics.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Colorcon
Healthtrust
Boehringer Ingelheim
Chubb
Cantor Fitzgerald
Teva
US Army
Chinese Patent Office
Queensland Health
Daiichi Sankyo

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot