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Details for Patent: 4,886,668

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Details for Patent: 4,886,668

Title: Multiparticulate controlled porosity osmotic pump
Abstract:The instant invention is directed to a multiparticulate osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (I) a carrier medium which does not maintain its integrity in the environment of use; (II) a multiple of tiny osmotic pump elements each comprising: (A) a core comprises diltiazem L-malate and an effective buffering amount of sodium bitartrate surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6.96.times.10.sup.-18 to 6.96.times.10.sup.-14 cm.sup.3 sec/g and a reflection coefficient of less than 0.5, prepared from: (i) a polymer permeable to water but impermeable to solute and (ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall, wherein the total amount of diltiazem L-malate in all of the osmotic pump elements is a therapeutically effective amount.
Inventor(s): Haslam; John L. (Lawrence, KS), Rork; Gerald S. (Lawrence, KS)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Sep 24, 1987
Application Number:07/100,676
Claims:1. A multiparticulate osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising:

(I) a carrier medium which does not maintain its integrity in the environment of use;

(II) a multiple of tiny osmotic pump elements each comprising:

(A) a core which comprises diltiazem L malate and between 80 and 150 percent by weight of sodium bitartrate surrounded by

(B) a rate controlling water insoluble wall, having a fluid permeability of 6.96.times. 10.sup.-18 to 6.96.times.10.sup..times.14 cm.sup.3 sec/g and a reflection coefficient of less than 0.5, prepared from:

(i) a polymer permeable to impermeable to solute and

(ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall,

wherein the total amount of diltiazem L-malate in all of the osmotic pump elements is a therapeutically effective amount.

2. An osmotic pump according to claim 1 wherein the total amount of diltiazem L-malate in the core of all the osmotic pump elements is between 30 and 500 mg.

3. An osmotic pump according to claim 1 wherein the total amount of sodium bitartrate in the core of all the osmotic pump elements is between 30 and 500 mg.

4. An osmotic pump according to claim 1, wherein said pore forming additive comprises:

(a) 0.1 to 50%, by weight, solid additive, based on the total weight of (i) and (ii), and/or

(b) 0.1 to 40%, by weight, liquid additive, based on the total weight of (i) and (ii), not to exceed a total weight % of pore forming additive of 60%.

5. An osmotic pump according to claim 4 wherein said wall is 10 to 500 microns thick and wall pores are between 10 angstroms and 25 microns in diameter.

6. An osmotic pump according to claim 1, wherein said reflection coefficient is less than 0.1.

7. An osmotic pump according to claim 1, further comprising:

(c) 0 to 50 parts per 100 parts of (i) and (ii) of plasticizer and flux regulating additives and

(d) 0 to 40 parts per 100 parts of (i) and (ii), of surfactant additive.

8. An osmotic pump according to claim 1, wherein said water insolube wall is 1 to 1,000 microns thick and wherein 5 to 95% of the resulting wall pores are between 10 angstroms and 100 microns in diameter.

9. An osmotic pump according to claim 1, wherein said polymer is selected from the group consisting of cellulose esters, acylated polysaccharides, polyurethane, polymers of acrylic and methacrylic acid and esters thereof, poly (ortho ester)s, polyacetals and mixtures thereof.

10. An osmotic pump according to claim 9, wherein said polymer is selected from the group consisting of cellulose esters and acylated polysaccharides.

11. An osmotic pump according to claim 9, wherein said polymer is selected from the group consisting of polyurethanes and polymers of acrylic and methacrylic acid and esters thereof.

12. An osmotic pump according to claim 9, wherein said polymer is selected from the group consisting of poly(ortho ester)s and polyacetals.

13. An osmotic pump according to claim 1, wherein said pore forming additive is selected from the group consisting of water, alkali metal salts, alkaline earth metal salts, saccharides, aliphatic polyols, aromatic polyols and mixtures thereof.

14. An osmotic pump according to claim 1, wherein 0.1 to 50%, by weight, of said pore forming additive is used.

15. An osmotic pump according to claim 1, wherein said pH insensitive pore forming additive is selected from the group consisting of polyethylene glycol, sorbitol, glucose and mixtures thereof.

16. An osmotic pump according to claim 1, further comprising:

additional pellets or multiparticulates of a therapeutically effective amount of a cardiovascular agent and a pharmaceutically acceptable carrier within the carrier medium; or

an external layer of a pharmaceutically acceptable carrier and a therapeutically effective amount of a cardiovascular agent on the tiny osmotic pump elements.

17. An osmotic pump according to claim 16 wherein the cardiovascular agent is selected from alpha receptor blocking agents, alpha and beta receptor blocking agents, angiotensin converting enzyme inhibitors, antianginal agents, antiarrhythmics, antiembolus agents, antihypertensives, beta blocking agents, digitalis, hemorheologic agents, inotropic agents, myocardial infarction propylaxis, quinidine, cerebral vasodilators, coronary vasodilators, peripheral vasodilators, and vasopressors.

18. An osmotic pump according to claim 17 wherein the cardiovascular agent is selected from angiotensin converting enzyme inhibitors.

19. An osmotic pump according to claim 18 wherein the angiotensin converting enzyme inhibitor is selected from captopril, enalapril and lisinopril.

20. The osmotic pump of claim 1 wherein the carrier medium is solid.

21. The osmotic pump of claim 20 wherein the solid carrier medium is a soluble gelatin capsule or tablet matrix.

22. The osmotic pump of claim 21 wherein the solid carrier medium is a soluble gelatin capsule.
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