Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Treatment of allograft rejection with mycophenolic acid, its morpholinoethylester and derivatives thereof|
|Abstract:||The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, Y is hydrogen or morpholinoethyl, and where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, particularly for treatment of allograft rejection, especially including cardiac allograft rejection, pancreatic allograft rejection and renal allograft rejection, and for treating autoimmune diabetes. ##STR1##|
|Inventor(s):||Allison; Anthony C. (Belmont, CA), Eugui; Elsie M. (Belmont, CA), Nelson; Peter H. (Los Altos, CA), Gu; Chee-Liang L. (Sunnyvale, CA), Lee; William A. (Palo Alto, CA)|
|Assignee:||Syntex (U.S.A.) Inc. (Palo Alto, CA)|
|Filing Date:||Aug 17, 1988|
|Claims:||1. A method of immunosuppressive treatment, particularly for treatment of allograft rejection in mammals, which comprises administering to a mammal in need thereof 0.4 to 30 mg/kg per day of a compound represented by the formula: ##STR8## wherein: Y is hydrogen and |
Z is hydrogen or --C(O)R,
where R is lower alkyl or aryl; or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 comprising a method of treating cardiac allograft rejection, pancreatic allograft rejection or renal allograft rejection.
3. The method of claim 2 wherein Z is hydrogen.
4. The method of claim 1 wherein Z is hydrogen.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.